PMID- 19004450
OWN - NLM
STAT- MEDLINE
DCOM- 20090219
LR  - 20181201
IS  - 0021-9673 (Print)
IS  - 0021-9673 (Linking)
VI  - 1214
IP  - 1-2
DP  - 2008 Dec 19
TI  - Determination of neonicotinoid insecticides residues in bovine milk samples by 
      solid-phase extraction clean-up and liquid chromatography with diode-array 
      detection.
PG  - 115-20
LID - 10.1016/j.chroma.2008.10.088 [doi]
AB  - In this paper we have developed an analytical method for the simultaneous 
      determination of four nicotinoid insecticides [acetamiprid (ACT), imidacloprid 
      (ICL), thiacloprid (TCL) and thiamethoxam (TMX)] in bovine whole milk. These 
      analytes were extracted, in a single step with dichloromethane, from fortified 
      milk samples, using Chem Elut cartridges, containing diatomaceous earth material. 
      Insecticide's determination and quantification were performed by HPLC with 
      diode-array detection (DAD). Average recoveries of the four insecticides from 
      bovine milk samples were between 85.1 and 99.7% at spiking levels 0.01, 0.05 and 
      0.1 mg kg(-1). Relative standard deviations (RSDs) were no larger than 10% for 
      all of the recovery tests. The calculated limits of quantitation (LOQ) ranged 
      from 0.01 to 0.04 mg kg(-1) for the four insecticides, being equal to or lower 
      than the maximum residue limits (MRLs) established by European legislation 
      (0.01-0.05 mg kg(-1)). The developed method is linear at concentrations within 
      the tested interval, with coefficients of determination higher than 0.9990. 
      According to Commission Decision 2002/657/EC, decision limit (CCalpha) and 
      detection capability (CCbeta) have been calculated. The proposed method is rapid, 
      simple and could be utilized for the routine analysis of pesticides residues.
FAU - Seccia, Serenella
AU  - Seccia S
AD  - Dipartimento di Chimica Farmaceutica e Tossicologica, Universita degli Studi di 
      Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy. seccia@unina.it
FAU - Fidente, Paola
AU  - Fidente P
FAU - Montesano, Domenico
AU  - Montesano D
FAU - Morrica, Patrizia
AU  - Morrica P
LA  - eng
PT  - Journal Article
DEP - 20081030
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Imidazoles)
RN  - 0 (Insecticides)
RN  - 0 (Neonicotinoids)
RN  - 0 (Nitro Compounds)
RN  - 0 (Oxazines)
RN  - 0 (Pesticide Residues)
RN  - 0 (Pyridines)
RN  - 0 (Thiazines)
RN  - 0 (Thiazoles)
RN  - 3BN7M937V8 (imidacloprid)
RN  - 5HL5N372P0 (acetamiprid)
RN  - 747IC8B487 (Thiamethoxam)
RN  - DSV3A944A4 (thiacloprid)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Food Contamination/*analysis
MH  - Imidazoles/analysis
MH  - Insecticides/*analysis
MH  - Least-Squares Analysis
MH  - Milk/*chemistry
MH  - Neonicotinoids
MH  - Nitro Compounds/analysis
MH  - Oxazines/analysis
MH  - Pesticide Residues/*analysis
MH  - Pyridines/analysis
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - *Solid Phase Extraction
MH  - Thiamethoxam
MH  - Thiazines/analysis
MH  - Thiazoles/analysis
EDAT- 2008/11/14 09:00
MHDA- 2009/02/20 09:00
CRDT- 2008/11/14 09:00
PHST- 2008/07/01 00:00 [received]
PHST- 2008/10/02 00:00 [revised]
PHST- 2008/10/24 00:00 [accepted]
PHST- 2008/11/14 09:00 [pubmed]
PHST- 2009/02/20 09:00 [medline]
PHST- 2008/11/14 09:00 [entrez]
AID - S0021-9673(08)01884-0 [pii]
AID - 10.1016/j.chroma.2008.10.088 [doi]
PST - ppublish
SO  - J Chromatogr A. 2008 Dec 19;1214(1-2):115-20. doi: 10.1016/j.chroma.2008.10.088. 
      Epub 2008 Oct 30.