PMID- 19005076
OWN - NLM
STAT- MEDLINE
DCOM- 20090126
LR  - 20211020
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 28
IP  - 46
DP  - 2008 Nov 12
TI  - Microtubules in dendritic spine development.
PG  - 12120-4
LID - 10.1523/JNEUROSCI.2509-08.2008 [doi]
AB  - It is generally believed that only the actin cytoskeleton resides in dendritic 
      spines and controls spine morphology and plasticity. Here, we report that 
      microtubules (MTs) are present in spines and that shRNA knockdown of the MT 
      plus-end-binding protein EB3 significantly reduces spine formation. Furthermore, 
      stabilization and inhibition of MTs by low doses of taxol and nocodazole enhance 
      and impair spine formation elicited by BDNF (brain-derived neurotrophic factor), 
      respectively. Therefore, MTs play an important role in the control and regulation 
      of dendritic spine development and plasticity.
FAU - Gu, Jiaping
AU  - Gu J
AD  - Department of Neuroscience and Cell Biology, University of Medicine and Dentistry 
      of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, 
      USA.
FAU - Firestein, Bonnie L
AU  - Firestein BL
FAU - Zheng, James Q
AU  - Zheng JQ
LA  - eng
GR  - R21 AG029596-02/AG/NIA NIH HHS/United States
GR  - R01 GM083889-10/GM/NIGMS NIH HHS/United States
GR  - AG029596/AG/NIA NIH HHS/United States
GR  - R21 AG029596/AG/NIA NIH HHS/United States
GR  - GM083889/GM/NIGMS NIH HHS/United States
GR  - R01 GM083889/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (EB3 protein, mouse)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Tubulin Modulators)
RN  - P88XT4IS4D (Paclitaxel)
RN  - SH1WY3R615 (Nocodazole)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism/pharmacology
MH  - Cells, Cultured
MH  - Dendritic Spines/metabolism/*ultrastructure
MH  - Down-Regulation/drug effects/physiology
MH  - Hippocampus/*embryology/metabolism/*ultrastructure
MH  - Microtubule-Associated Proteins/genetics/metabolism
MH  - Microtubules/metabolism/*ultrastructure
MH  - Neurogenesis/*physiology
MH  - Neuronal Plasticity/drug effects/physiology
MH  - Nocodazole/pharmacology
MH  - Paclitaxel/pharmacology
MH  - RNA Interference
MH  - Rats
MH  - Synapses/metabolism/ultrastructure
MH  - Tubulin Modulators/pharmacology
PMC - PMC2605155
MID - NIHMS79794
EDAT- 2008/11/14 09:00
MHDA- 2009/01/27 09:00
PMCR- 2009/05/12
CRDT- 2008/11/14 09:00
PHST- 2008/11/14 09:00 [pubmed]
PHST- 2009/01/27 09:00 [medline]
PHST- 2008/11/14 09:00 [entrez]
PHST- 2009/05/12 00:00 [pmc-release]
AID - 28/46/12120 [pii]
AID - 3413900 [pii]
AID - 10.1523/JNEUROSCI.2509-08.2008 [doi]
PST - ppublish
SO  - J Neurosci. 2008 Nov 12;28(46):12120-4. doi: 10.1523/JNEUROSCI.2509-08.2008.