PMID- 19006567
OWN - NLM
STAT- MEDLINE
DCOM- 20090303
LR  - 20090105
IS  - 1365-2141 (Electronic)
IS  - 0007-1048 (Linking)
VI  - 144
IP  - 2
DP  - 2009 Jan
TI  - Cytogenetics of paediatric and adolescent acute lymphoblastic leukaemia.
PG  - 147-56
LID - 10.1111/j.1365-2141.2008.07417.x [doi]
AB  - Cytogenetics has determined the incidence and prognostic significance of 
      chromosomal abnormalities in acute lymphoblastic leukaemia (ALL). The development 
      of fluorescence in situ hybridization (FISH) and array technologies has led to 
      the discovery of novel aberrations. Five 'hot topics' are presented in which 
      cytogenetics and related techniques have been instrumental in understanding the 
      role of genetics in leukaemogenesis: (i) genetic changes are integral to the 
      biology of T-cell ALL; (ii) intrachromosomal amplification of chromosome 21 is a 
      new recurrent abnormality in precursor-B ALL (BCP-ALL); (iii) the immunoglobulin 
      heavy chain gene (IGH@) is significant in BCP-ALL; (iv) alterations in genes 
      involved in B-cell development and cell cycle control contribute to the 
      pathogenesis of BCP-ALL; (v) age-related cytogenetic profiles define ALL in 
      children and adolescents as distinct biological entities. In this molecular era, 
      cytogenetics continues to be integral to our understanding of the genetics of 
      this disease.
FAU - Harrison, Christine J
AU  - Harrison CJ
AD  - Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, 
      Newcastle University, Newcastle-upon-Tyne, UK. christine.harrison@newcastle.ac.uk
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20081101
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - Adolescent
MH  - Child
MH  - *Chromosome Aberrations
MH  - Comparative Genomic Hybridization
MH  - *Cytogenetic Analysis
MH  - Gene Expression Profiling
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Oligonucleotide Array Sequence Analysis
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics/pathology
RF  - 74
EDAT- 2008/11/14 09:00
MHDA- 2009/03/04 09:00
CRDT- 2008/11/14 09:00
PHST- 2008/11/14 09:00 [pubmed]
PHST- 2009/03/04 09:00 [medline]
PHST- 2008/11/14 09:00 [entrez]
AID - BJH7417 [pii]
AID - 10.1111/j.1365-2141.2008.07417.x [doi]
PST - ppublish
SO  - Br J Haematol. 2009 Jan;144(2):147-56. doi: 10.1111/j.1365-2141.2008.07417.x. 
      Epub 2008 Nov 1.