PMID- 19007989
OWN - NLM
STAT- MEDLINE
DCOM- 20100713
LR  - 20171116
IS  - 1878-1667 (Electronic)
IS  - 0147-9571 (Linking)
VI  - 33
IP  - 3
DP  - 2010 May
TI  - Toll-Like Receptor expressions in porcine alveolar macrophages and Dendritic 
      Cells in responding to poly IC stimulation and porcine reproductive and 
      respiratory syndrome virus (PRRSV) infection.
PG  - 197-213
LID - 10.1016/j.cimid.2008.10.001 [doi]
AB  - Antigen-presenting cells play critical roles in recognizing, presenting and 
      processing antigens and consequently induce adequate immune response for 
      defending infections. The immature DCs (imDCs) and mature DCs (mDCs) were 
      obtained from in vitro differentiation of bone marrow haematopoietic cells. 
      Results showed that poly IC stimulation down-regulated the expressions of TLR7 
      and TLR8 in alveolar macrophages (AMs) and imDCs. The release of IL-12 was 
      inhibited from imDCs and mDCs in response to poly IC. Porcine reproductive and 
      respiratory syndrome virus (PRRSV)-infection inhibited TLR3 and TLR7 expressions 
      in AMs and imDCs at 6h post-infection (PI); both of expressions were then 
      restored at 24h PI in both types of cells while they exhibited up-regulated IL-10 
      and IL-12 expression at 24h PI. Hence, the differential TLR expression patterns 
      in porcine AMs and DCs in discrimination of the imitated viral dsRNA or PRRSV 
      infection may determine their cytokine expressions and thus affect the resulting 
      immune responses.
FAU - Chaung, Hso-Chi
AU  - Chaung HC
AD  - Department of Veterinary Medicine, National Pingtung University of Science and 
      Technology, Pingtung, Taiwan, ROC. hcchaung@mail.npust.edu.tw
FAU - Chen, Chien-Wei
AU  - Chen CW
FAU - Hsieh, Bing-Lun
AU  - Hsieh BL
FAU - Chung, Wen-Bin
AU  - Chung WB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081112
PL  - England
TA  - Comp Immunol Microbiol Infect Dis
JT  - Comparative immunology, microbiology and infectious diseases
JID - 7808924
RN  - 0 (Antiviral Agents)
RN  - 0 (Toll-Like Receptor 3)
RN  - 0 (Toll-Like Receptor 7)
RN  - 0 (Toll-Like Receptor 8)
RN  - 0 (Toll-Like Receptors)
RN  - 130068-27-8 (Interleukin-10)
RN  - 187348-17-0 (Interleukin-12)
RN  - O84C90HH2L (Poly I-C)
SB  - IM
MH  - Animals
MH  - Antiviral Agents/*pharmacology
MH  - Cell Culture Techniques
MH  - Dendritic Cells/*drug effects/*immunology/metabolism/virology
MH  - Female
MH  - Interleukin-10/biosynthesis/immunology
MH  - Interleukin-12/biosynthesis/immunology
MH  - Macrophages, Alveolar/*drug effects/*immunology/metabolism/virology
MH  - Poly I-C/*pharmacology
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology/virology
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - Swine
MH  - Time Factors
MH  - Toll-Like Receptor 3/biosynthesis/immunology
MH  - Toll-Like Receptor 7/biosynthesis/immunology
MH  - Toll-Like Receptor 8/biosynthesis/immunology
MH  - *Toll-Like Receptors/biosynthesis/immunology
EDAT- 2008/11/15 09:00
MHDA- 2010/07/14 06:00
CRDT- 2008/11/15 09:00
PHST- 2008/10/04 00:00 [accepted]
PHST- 2008/11/15 09:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
PHST- 2008/11/15 09:00 [entrez]
AID - S0147-9571(08)00057-X [pii]
AID - 10.1016/j.cimid.2008.10.001 [doi]
PST - ppublish
SO  - Comp Immunol Microbiol Infect Dis. 2010 May;33(3):197-213. doi: 
      10.1016/j.cimid.2008.10.001. Epub 2008 Nov 12.