PMID- 19009040
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211028
IS  - 1687-4757 (Print)
IS  - 1687-4765 (Electronic)
VI  - 2008
DP  - 2008
TI  - Potential Therapeutic Use of PPARgamma-Programed Human Monocyte-Derived Dendritic 
      Cells in Cancer Vaccination Therapy.
PG  - 473804
LID - 10.1155/2008/473804 [doi]
LID - 473804
AB  - Dendritic cells (DCs) can regulate all elements of the immune system, and 
      therefore are an ideal target for vaccination. During the last two decades, as a 
      result of extensive research, DCs became the primary target of antitumor 
      vaccination as well. A critical issue of antitumor vaccination is the phenotype 
      of the dendritic cell used. It has been recently shown that several nuclear 
      hormone receptors, and amongst them the lipid-activated nuclear receptor and 
      peroxisome proliferator-activated receptor gamma (PPARgamma), have important 
      roles in effecting the immunophenotype of human dendritic cells. It regulates 
      primarily lipid metabolism and via this it influences the immunophenotype of DCs 
      by altering lipid antigen uptake, presentation, and also other immune functions. 
      In this review, we summarize the principles of antitumor vaccination strategies 
      and present our hypothesis on how PPARgamma-regulated processes might be involved 
      and could be exploited in the design of vaccination strategies.
FAU - Gyongyosi, Adrienn
AU  - Gyongyosi A
AD  - Department of Biochemistry and Molecular Biology, Medical and Health Science 
      Center, University of Debrecen, 4010 Debrecen, Egyetem ter 1, Life Science 
      Building, 4010 Debrecen, Hungary.
FAU - Nagy, Laszlo
AU  - Nagy L
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20081105
PL  - United States
TA  - PPAR Res
JT  - PPAR research
JID - 101269101
PMC - PMC2581789
EDAT- 2008/11/15 09:00
MHDA- 2008/11/15 09:01
PMCR- 2008/11/05
CRDT- 2008/11/15 09:00
PHST- 2008/07/15 00:00 [received]
PHST- 2008/09/22 00:00 [accepted]
PHST- 2008/11/15 09:00 [pubmed]
PHST- 2008/11/15 09:01 [medline]
PHST- 2008/11/15 09:00 [entrez]
PHST- 2008/11/05 00:00 [pmc-release]
AID - 10.1155/2008/473804 [doi]
PST - ppublish
SO  - PPAR Res. 2008;2008:473804. doi: 10.1155/2008/473804. Epub 2008 Nov 5.