PMID- 19009498
OWN - NLM
STAT- MEDLINE
DCOM- 20090323
LR  - 20151119
IS  - 1438-9010 (Electronic)
IS  - 1438-9010 (Linking)
VI  - 180
IP  - 12
DP  - 2008 Dec
TI  - Detection of myocardial fibrosis in systemic sclerosis by contrast-enhanced 
      magnetic resonance imaging.
PG  - 1054-60
LID - 10.1055/s-2008-1027864 [doi]
AB  - PURPOSE: Our study aimed to assess the prevalence and pattern of late gadolinium 
      enhancement (LGE) as an in vivo correlate of myocardial fibrosis in cardiac 
      asymptomatic patients with systemic sclerosis (SSc). MATERIALS AND METHODS: 
      Cardiac magnetic resonance imaging was successfully performed in 34 patients (30 
      female, 4 male, mean age of 54 +/- 14 years) with proven SSc and in controls with 
      matching age, sex and cardiovascular risk factors. All examinations were 
      performed on a 1.5 T MR system (Avanto, Siemens, Germany). 2D inversion recovery 
      spoiled gradient echo images (TR 8.0 msec, TE 4.0 msec, TI 180 - 240 msec, FA 20 
      degrees, slice thickness 8 mm, in-plane resolution 1.2 x 1.2 mm (2)) were 
      acquired 10 to 15 min after injection of 0.2 mmol Gd-DTPA per kg body weight to 
      detect myocardial LGE. RESULTS: Poorly defined, patchy as well as well-defined 
      focal areas of LGE were detected predominantly in the mid-myocardial layer of the 
      basal left ventricular segments in 5 of 34 (15 %) SSc patients. A focal area of 
      LGE was observed within the apical septum in one control (3 %, p > 0.05). LGE was 
      observed in a total of 15 segments of the SSc patients and in 1 segment of the 
      controls (p < 0.005). CONCLUSION: Our results revealed a significantly higher 
      number of LGE positive segments in patients with SSc compared to matched 
      controls, and demonstrate the ability of contrast-enhanced MRI to detect 
      myocardial fibrosis, the hallmark of scleroderma heart disease, in-vivo.
FAU - Nassenstein, K
AU  - Nassenstein K
AD  - Abteilung fur Diagnostische und Interventionelle Radiologie und Neuroradiologie, 
      Universitatsklinikum Essen, Essen. Kai.Nassenstein@uni-due.de
FAU - Breuckmann, F
AU  - Breuckmann F
FAU - Huger, M
AU  - Huger M
FAU - Ladd, S C
AU  - Ladd SC
FAU - Schlosser, T
AU  - Schlosser T
FAU - Kreuter, A
AU  - Kreuter A
FAU - Barkhausen, J
AU  - Barkhausen J
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20081113
PL  - Germany
TA  - Rofo
JT  - RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin
JID - 7507497
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - *Contrast Media
MH  - Cross-Sectional Studies
MH  - Endomyocardial Fibrosis/*diagnosis/epidemiology
MH  - Female
MH  - *Gadolinium DTPA
MH  - Heart Septum/pathology
MH  - Heart Ventricles/pathology
MH  - Humans
MH  - *Image Processing, Computer-Assisted
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardium/pathology
MH  - Pericardial Effusion/diagnosis/epidemiology
MH  - Scleroderma, Systemic/*diagnosis/epidemiology
EDAT- 2008/11/15 09:00
MHDA- 2009/03/24 09:00
CRDT- 2008/11/15 09:00
PHST- 2008/11/15 09:00 [pubmed]
PHST- 2009/03/24 09:00 [medline]
PHST- 2008/11/15 09:00 [entrez]
AID - 10.1055/s-2008-1027864 [doi]
PST - ppublish
SO  - Rofo. 2008 Dec;180(12):1054-60. doi: 10.1055/s-2008-1027864. Epub 2008 Nov 13.