PMID- 19012000
OWN - NLM
STAT- MEDLINE
DCOM- 20090619
LR  - 20211020
IS  - 1355-008X (Print)
IS  - 1355-008X (Linking)
VI  - 33
IP  - 3
DP  - 2008 Jun
TI  - Evaluation of the effect of caloric restriction on serum BDNF in overweight and 
      obese subjects: preliminary evidences.
PG  - 300-4
LID - 10.1007/s12020-008-9090-x [doi]
AB  - Brain-derived neurotrophic factor (BDNF) has emerged as a new element related 
      with insulin resistance and obesity. OBJECTIVE: To evaluate the effect of a 
      3-month reduced-calorie diet (RCD) on serum BDNF concentrations in overweight and 
      obese subjects. SUBJECTS: Seventeen healthy overweight and obese subjects of both 
      sexes (24 - 48 years, BMI 34.6 +/- 1.1 kg/m2). METHODS: Anthropometry, oral 
      glucose tolerance test (OGTT), lipid levels, and serum BDNF were measured at 
      baseline and at the end of the third month. Reduced-calorie diet was defined as a 
      25% reduction in energy intake composed of: 55% carbohydrates, 20% proteins, and 
      25% fat (less than 10% saturated fat and over 10% nonsaturated fat). Refined 
      sugar was not allowed. RESULTS: There was a significant decrease in BMI, waist 
      circumference, body fat percentage, fasting glucose, post-OGTT glucose levels, 
      area under the curve of glucose, and HOMA2-IR after 3 months of RCD. Serum BDNF 
      showed a significant increase (3.97 +/- 0.87 to 6.75 +/- 1.62 ng/ml, P = 0.02). 
      Final serum BDNF correlated negatively with weight (r = -0.51, P = 0.03), and 
      basal post-OGTT insulin correlated positively with final serum BDNF (r = 0.48, P 
      = 0.04). CONCLUSIONS: Serum BDNF increases in insulin-resistant overweight and 
      obese subjects after three months on a RCD. This observation could indicate that 
      BDNF may be modulated in humans through diet composition.
FAU - Araya, A Veronica
AU  - Araya AV
AD  - Endocrinology Section, Department of Internal Medicine, University of Chile 
      Clinical Hospital, Santos Dumont 999, Independencia, Santiago, Chile. 
      varaya@redclinicauchile.cl
FAU - Orellana, Ximena
AU  - Orellana X
FAU - Espinoza, Jaime
AU  - Espinoza J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - *Caloric Restriction
MH  - Diet, Reducing
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin Resistance/*physiology
MH  - Male
MH  - Middle Aged
MH  - Obesity/*blood/diet therapy
MH  - Overweight/*blood/diet therapy
MH  - Waist Circumference
MH  - Weight Loss/physiology
MH  - Young Adult
EDAT- 2008/11/18 09:00
MHDA- 2009/06/20 09:00
CRDT- 2008/11/18 09:00
PHST- 2008/03/10 00:00 [received]
PHST- 2008/06/26 00:00 [accepted]
PHST- 2008/11/18 09:00 [pubmed]
PHST- 2009/06/20 09:00 [medline]
PHST- 2008/11/18 09:00 [entrez]
AID - 10.1007/s12020-008-9090-x [doi]
PST - ppublish
SO  - Endocrine. 2008 Jun;33(3):300-4. doi: 10.1007/s12020-008-9090-x.