PMID- 19012207
OWN - NLM
STAT- MEDLINE
DCOM- 20090226
LR  - 20181201
IS  - 0171-6425 (Print)
IS  - 0171-6425 (Linking)
VI  - 56
IP  - 8
DP  - 2008 Dec
TI  - Different biological properties of circulating and bone marrow endothelial 
      progenitor cells in acute myocardial infarction rats.
PG  - 441-8
LID - 10.1055/s-2008-1038879 [doi]
AB  - BACKGROUND: Many studies have shown that endothelial progenitor cell (EPC) can 
      enhance the neovascularization of the ischemic myocardium. Peripheral blood and 
      bone marrow are the most convenient resources for EPC. OBJECTIVE: The aim of the 
      study was to investigate, in vitro and in vivo, the different biological 
      properties between circulating EPC (CEPC) and bone marrow EPC (BM-EPC) of AMI 
      rats. METHODS: The proliferative, migrative, adherent and angiogenic properties 
      were investigated in vitro. 1 x 10 (6) CEPCs, 1 x 10 (6) BM-EPCs and medium 
      (EBM-2) were injected in the myocardium of AMI rats. Echocardiography, regional 
      myocardial blood flow (RMBF), capillary density and Y chromosome fluorescence in 
      situ hybridization (FISH) were performed at 4 weeks after transplantation. 
      RESULTS: The CEPCs had higher proliferative, migrative, adherent capabilities and 
      lower senescent ratio, could adhere more quickly to fibronectin than BM-EPCs. 
      CEPCs could form capillary-like structures whereas BM-EPCs did not show similar 
      structures on Matrigel. in vivo, transplanted CEPCs and BM-EPCs were found in 
      cardiac tissue by FISH. CEPCs treatment led to a better cardiac function, RMBF 
      and capillary density than BM-EPCs. CONCLUSION: Different biological properties 
      were observed between CEPCs and BM-EPCs. Autologous CEPCs are more suitable for 
      the AMI rat.
FAU - Xin, Z
AU  - Xin Z
AD  - The Division of Cardiology, Shanghai Sixth Hospital, Shanghai JiaoTong University 
      School of Medicine, Shanghai, China.
FAU - Meng, W
AU  - Meng W
FAU - Ya-Ping, H
AU  - Ya-Ping H
FAU - Wei, Z
AU  - Wei Z
LA  - eng
PT  - Journal Article
DEP - 20081114
PL  - Germany
TA  - Thorac Cardiovasc Surg
JT  - The Thoracic and cardiovascular surgeon
JID - 7903387
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells/cytology/*physiology
MH  - Cell Adhesion
MH  - Cell Movement
MH  - Cells, Cultured
MH  - Colony-Forming Units Assay
MH  - Female
MH  - Flow Cytometry
MH  - In Situ Hybridization, Fluorescence
MH  - Intercellular Signaling Peptides and Proteins/metabolism
MH  - Male
MH  - Myocardial Infarction/*therapy
MH  - Neovascularization, Physiologic
MH  - Pluripotent Stem Cells/cytology/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Stem Cell Transplantation
EDAT- 2008/11/18 09:00
MHDA- 2009/02/27 09:00
CRDT- 2008/11/18 09:00
PHST- 2008/11/18 09:00 [pubmed]
PHST- 2009/02/27 09:00 [medline]
PHST- 2008/11/18 09:00 [entrez]
AID - 10.1055/s-2008-1038879 [doi]
PST - ppublish
SO  - Thorac Cardiovasc Surg. 2008 Dec;56(8):441-8. doi: 10.1055/s-2008-1038879. Epub 
      2008 Nov 14.