PMID- 19013140
OWN - NLM
STAT- MEDLINE
DCOM- 20090213
LR  - 20220316
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 400
IP  - 1-2
DP  - 2009 Feb
TI  - BDNF Val66Met polymorphism is associated with unstable angina.
PG  - 3-7
LID - 10.1016/j.cca.2008.10.017 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) is involved in the 
      pathophysiology of coronary artery disease (CAD). The human BDNF Val66Met 
      polymorphism has been shown to be associated with altered susceptibility to 
      neuropsychiatric disorders. However it is unknown whether this polymorphism plays 
      a role in cardiovascular disease. METHODS: Genotyping of BDNF Val66Met 
      polymorphism was carried out in 513 controls, 628 unstable angina pectoris (UAP) 
      and 276 stable angina pectoris (SAP) patients. The plasma concentrations of BDNF 
      and high-sensitivity C-reactive protein (hsCRP) were measured by ELISA. The 
      general clinical data in patients and controls were obtained. RESULTS: There was 
      a significant association between genotype and allele frequency of the BDNF 
      Val66Met polymorphism and UAP (all P<0.05). Multivariate logistic regression 
      analysis revealed that the BDNF(Met/Met) genotype had a protective effect on the 
      occurrence of UAP after controlling for known risk factors of CAD (OR 0.53, 
      P=0.005). Subjects with BDNF(Met/Met) genotype also had decreased plasma hsCRP 
      levels compared with the Val carriers (P<0.01). CONCLUSION: The BDNF(Met/Met) 
      genotype has a protective effect on the occurrence of UAP, which might in part be 
      due to the decreased plasma hsCRP level in BDNF(Met/Met) carriers. To our 
      knowledge, this is the first study that demonstrates the link between BDNF 
      Val66Met polymorphism and CAD.
FAU - Jiang, Hong
AU  - Jiang H
AD  - Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese 
      Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong 
      University, Jinan, Shandong 250012, China.
FAU - Wang, Rong
AU  - Wang R
FAU - Liu, Yan
AU  - Liu Y
FAU - Zhang, Yun
AU  - Zhang Y
FAU - Chen, Zhe-Yu
AU  - Chen ZY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081030
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
CIN - Clin Chim Acta. 2009 Feb;400(1-2):1-2. PMID: 19013442
MH  - Angina, Unstable/blood/complications/*genetics
MH  - Brain-Derived Neurotrophic Factor/blood/*genetics
MH  - C-Reactive Protein/metabolism
MH  - Case-Control Studies
MH  - Coronary Artery Disease/blood/complications/genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
EDAT- 2008/11/18 09:00
MHDA- 2009/02/14 09:00
CRDT- 2008/11/18 09:00
PHST- 2008/04/15 00:00 [received]
PHST- 2008/08/12 00:00 [revised]
PHST- 2008/10/16 00:00 [accepted]
PHST- 2008/11/18 09:00 [pubmed]
PHST- 2009/02/14 09:00 [medline]
PHST- 2008/11/18 09:00 [entrez]
AID - S0009-8981(08)00526-3 [pii]
AID - 10.1016/j.cca.2008.10.017 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2009 Feb;400(1-2):3-7. doi: 10.1016/j.cca.2008.10.017. Epub 2008 
      Oct 30.