PMID- 1901333
OWN - NLM
STAT- MEDLINE
DCOM- 19910506
LR  - 20190510
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 163
IP  - 4
DP  - 1991 Apr
TI  - Tumor necrosis factor (cachectin) in human visceral leishmaniasis.
PG  - 853-7
AB  - High tumor necrosis factor-alpha (TNF alpha) levels were present in the serum of 
      24 of 28 active visceral leishmaniasis (VL) patients (142.9 +/- 113.9 pg/ml, mean 
      +/- SD), whereas levels were not elevated in 26 of 30 patients with cryptic 
      leishmanial infection (16 asymptomatic, 4 with self-healing subclinical 
      infection, and 10 posttreatment VL cases). Serum TNF alpha levels were also not 
      elevated in 15 normal volunteers (11.3 +/- 15.6 pg/ml) and in 10 patients with 
      tegumentary leishmaniasis (19.1 +/- 10.8 pg/ml). Leishmanial infection of human 
      monocyte-derived macrophages enhanced the basal TNF alpha production by these 
      cells, and this effect was further potentiated by treatment with recombinant 
      interferon-gamma. After effective treatment of VL patients, serum TNF alpha 
      levels dropped rapidly (129 +/- 112 vs. 9 +/- 13 pg/ml in 10 days), even before 
      clinical parameters such as spleen size or parasitism, white blood cell count, or 
      levels of hemoglobin returned to normal values. On the other hand, patients 
      unresponsive to treatment remained with elevated levels (276 +/- 69 vs. 155 +/- 
      71 pg/ml in 10 days). Thus, serum TNF alpha levels in VL patients are a good 
      parameter to monitor in determining host response to therapy.
FAU - Barral-Netto, M
AU  - Barral-Netto M
AD  - Servicco de Immunologia, Hospital Universidade Professor Edgard Santos, 
      Universidade Federal de Bahia, Salvador-Bahia, Brazil.
FAU - Badaro, R
AU  - Badaro R
FAU - Barral, A
AU  - Barral A
FAU - Almeida, R P
AU  - Almeida RP
FAU - Santos, S B
AU  - Santos SB
FAU - Badaro, F
AU  - Badaro F
FAU - Pedral-Sampaio, D
AU  - Pedral-Sampaio D
FAU - Carvalho, E M
AU  - Carvalho EM
FAU - Falcoff, E
AU  - Falcoff E
FAU - Falcoff, R
AU  - Falcoff R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antiprotozoal Agents)
RN  - 0 (Organometallic Compounds)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 6HG8UB2MUY (Meglumine)
RN  - 75G4TW236W (Meglumine Antimoniate)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9IT35J3UV3 (Antimony)
SB  - IM
MH  - Acute Disease
MH  - Antimony/therapeutic use
MH  - Antiprotozoal Agents/therapeutic use
MH  - Cells, Cultured
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Interferon-gamma/pharmacology/therapeutic use
MH  - Leishmaniasis, Visceral/*blood/diagnosis/therapy
MH  - Macrophages/drug effects/parasitology
MH  - Male
MH  - Meglumine/therapeutic use
MH  - Meglumine Antimoniate
MH  - Organometallic Compounds/therapeutic use
MH  - Recombinant Proteins
MH  - Tumor Necrosis Factor-alpha/*analysis
EDAT- 1991/04/01 00:00
MHDA- 1991/04/01 00:01
CRDT- 1991/04/01 00:00
PHST- 1991/04/01 00:00 [pubmed]
PHST- 1991/04/01 00:01 [medline]
PHST- 1991/04/01 00:00 [entrez]
AID - 10.1093/infdis/163.4.853 [doi]
PST - ppublish
SO  - J Infect Dis. 1991 Apr;163(4):853-7. doi: 10.1093/infdis/163.4.853.