PMID- 19014374
OWN - NLM
STAT- MEDLINE
DCOM- 20090408
LR  - 20091119
IS  - 1471-4159 (Electronic)
IS  - 0022-3042 (Linking)
VI  - 108
IP  - 1
DP  - 2009 Jan
TI  - Retinoic acid receptor-related orphan receptor alpha regulates a subset of cone 
      genes during mouse retinal development.
PG  - 91-101
LID - 10.1111/j.1471-4159.2008.05739.x [doi]
AB  - Color vision is supported by retinal cone photoreceptors that, in most mammals, 
      express two photopigments sensitive to short (S-opsin) or middle (M-opsin) 
      wavelengths. Expression of the Opn1sw and Opn1mw genes, encoding S-opsin and 
      M-opsin, respectively, is under the control of nuclear receptors, including 
      thyroid hormone receptor beta2 (TRbeta2), retinoid X receptor gamma (RXRgamma), 
      and RORbeta, a member of the retinoic acid receptor-related orphan receptor (ROR) 
      family. We now demonstrate that RORalpha, another member of the ROR family, 
      regulates Opn1sw, Opn1mw, as well as Arr3 (cone arrestin) in the mouse retina. 
      RORalpha expression is detected in cones by postnatal day 3 and maintained 
      through adulthood. The retinas of staggerer mice, carrying a null mutation of 
      RORalpha, show significant down-regulation of Opn1sw, Opn1mw, and Arr3. RORalpha 
      acts in synergy with cone-rod homeobox transcription factor (Crx), to activate 
      the Opn1sw promoter in vitro. Chromatin immunoprecipitation assays reveal that 
      RORalpha directly binds to the Opn1sw promoter, Opn1mw locus control region, and 
      the Arr3 promoter in vivo. Our data suggest that RORalpha plays a crucial role in 
      cone development by directly regulating multiple cone genes.
FAU - Fujieda, Hiroki
AU  - Fujieda H
AD  - Department of Anatomy, School of Medicine, Tokyo Women's Medical University, 
      Tokyo, Japan. hfujieda@research.twmu.ac.jp
FAU - Bremner, Rod
AU  - Bremner R
FAU - Mears, Alan J
AU  - Mears AJ
FAU - Sasaki, Hiroshi
AU  - Sasaki H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081108
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Arrestins)
RN  - 0 (Basic-Leucine Zipper Transcription Factors)
RN  - 0 (Eye Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Nrl protein, mouse)
RN  - 0 (Nuclear Receptor Subfamily 1, Group F, Member 1)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Rod Opsins)
RN  - 0 (Trans-Activators)
RN  - 0 (cone rod homeobox protein)
RN  - 0 (middle-wavelength opsin)
RN  - 0 (short-wavelength opsin)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Arrestins/metabolism
MH  - Basic-Leucine Zipper Transcription Factors/deficiency
MH  - Chromatin Immunoprecipitation/methods
MH  - Down-Regulation/*physiology
MH  - Embryo, Mammalian
MH  - Eye Proteins
MH  - Gene Expression Regulation, Developmental/*physiology
MH  - Homeodomain Proteins
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Mice, Neurologic Mutants
MH  - Nuclear Receptor Subfamily 1, Group F, Member 1
MH  - Receptors, Cytoplasmic and Nuclear/*physiology
MH  - *Retina/cytology/embryology/growth & development
MH  - Retinal Cone Photoreceptor Cells/*metabolism
MH  - Rod Opsins/metabolism
MH  - Trans-Activators/*physiology
MH  - Transfection
EDAT- 2008/11/19 09:00
MHDA- 2009/04/09 09:00
CRDT- 2008/11/19 09:00
PHST- 2008/11/19 09:00 [pubmed]
PHST- 2009/04/09 09:00 [medline]
PHST- 2008/11/19 09:00 [entrez]
AID - JNC5739 [pii]
AID - 10.1111/j.1471-4159.2008.05739.x [doi]
PST - ppublish
SO  - J Neurochem. 2009 Jan;108(1):91-101. doi: 10.1111/j.1471-4159.2008.05739.x. Epub 
      2008 Nov 8.