PMID- 19014891
OWN - NLM
STAT- MEDLINE
DCOM- 20090210
LR  - 20081219
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 44
IP  - 3
DP  - 2008 Dec
TI  - Monocyte chemoattractant protein-1 (MCP-1) gene polymorphism as a potential risk 
      factor for cardiovascular disease in hemodialyzed patients.
PG  - 361-5
LID - 10.1016/j.cyto.2008.10.001 [doi]
AB  - AIM: Polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene 
      (A-2518G) has been associated with functional effects. The aim of the present 
      study was to assess the effect of this polymorphism on end-stage renal disease 
      (ESRD) and cardiovascular disease (CVD) in hemodialyzed patients. METHODS: A 
      total of 720 patients with ESRD treated with hemodialysis (450 patients with CVD) 
      and 325 healthy control subjects were genotyped for the MCP-1 -2518 polymorphism 
      by the polymerase chain reaction-restriction fragment length polymorphism 
      (PCR-RFLP) procedure. RESULTS: There was a significant difference in genotype 
      frequencies between entire group of hemodialyzed patients and controls (p<0.01). 
      The odds ratio for the risk allele was 1.85, 95% CI 1.49-2.32 (p<0.01). 
      Hemodialyzed patients were divided into subgroups with CVD (n=450) and without 
      CVD (n=270). The G allele carriers occurred with significantly higher frequency 
      in patients with CVD (62% vs. 38% in patients without CVD and 36% in controls). 
      The odds ratio for the risk allele for patients with CVD vs. those without CVD 
      was 2.17, 95% CI 1.71-2.79. There was no statistically significant difference in 
      the distribution of MCP-1 genotypes between ESRD patients without CVD and healthy 
      controls. CONCLUSION: Our results demonstrate for the first time an association 
      between the polymorphism in the regulatory region of the MCP-1 gene and 
      susceptibility to CVD in hemodialyzed patients.
FAU - Buraczynska, Monika
AU  - Buraczynska M
AD  - Department of Nephrology, Laboratory for DNA Analysis and Molecular Diagnostics, 
      Medical University of Lublin, Dr K. Jaczewskiego 8, 20-954 Lublin, Poland. 
      monika.buraczynska@am.lublin.pl
FAU - Bednarek-Skublewska, Anna
AU  - Bednarek-Skublewska A
FAU - Buraczynska, Kinga
AU  - Buraczynska K
FAU - Ksiazek, Andrzej
AU  - Ksiazek A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081117
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Alleles
MH  - Cardiovascular Diseases/blood/epidemiology/*genetics
MH  - Chemokine CCL2/blood/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - *Renal Dialysis
MH  - Risk Factors
EDAT- 2008/11/19 09:00
MHDA- 2009/02/12 09:00
CRDT- 2008/11/19 09:00
PHST- 2008/04/04 00:00 [received]
PHST- 2008/09/26 00:00 [revised]
PHST- 2008/10/07 00:00 [accepted]
PHST- 2008/11/19 09:00 [pubmed]
PHST- 2009/02/12 09:00 [medline]
PHST- 2008/11/19 09:00 [entrez]
AID - S1043-4666(08)00759-X [pii]
AID - 10.1016/j.cyto.2008.10.001 [doi]
PST - ppublish
SO  - Cytokine. 2008 Dec;44(3):361-5. doi: 10.1016/j.cyto.2008.10.001. Epub 2008 Nov 
      17.