PMID- 19014937
OWN - NLM
STAT- MEDLINE
DCOM- 20090408
LR  - 20081219
IS  - 1090-2430 (Electronic)
IS  - 0014-4886 (Linking)
VI  - 215
IP  - 1
DP  - 2009 Jan
TI  - Impaired dendritic development and synaptic formation of postnatal-born dentate 
      gyrus granular neurons in the absence of brain-derived neurotrophic factor 
      signaling.
PG  - 178-90
LID - 10.1016/j.expneurol.2008.10.009 [doi]
AB  - Neurons are continuously added to the hippocampal dentate gyrus throughout life. 
      These neurons must develop dendritic arbors and spines by which they form 
      synapses for making functional connections with existing neurons. The molecular 
      mechanisms that regulate dendritic development and synaptic formation of 
      postnatal-born granular neurons in the dentate gyrus are largely unknown. 
      Hippocampal dentate gyrus (HDG) has been shown to express high level of 
      brain-derived neurotrophic factor (BDNF). Here we reported that when BDNF is 
      conditionally knockout in the postnatal-born granular neurons of the HDG, the 
      mutant neurons exhibit aberrant morphological development with less dendritic 
      branches, shorter dendritic length, and lower density of dendritic spines, while 
      their primary dendrites are not obviously affected. Even though, these 
      BDNF-deficient granular neurons develop immature dendritic spines to initiate 
      synaptic contacts with afferent axons, they fail to develop or maintain mature 
      spine structures. Thus, these postnatal-born neurons have fewer numbers of 
      synapses, particularly mature synaptic spines. These results suggest that BDNF 
      plays an important role during dendritic development, synaptic formation and 
      synaptic maturation in postnatal-born granular neurons of the HDG in vivo.
FAU - Gao, Xiang
AU  - Gao X
AD  - Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, 
      KY 40536, USA.
FAU - Smith, George M
AU  - Smith GM
FAU - Chen, Jinhui
AU  - Chen J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081030
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (enhanced green fluorescent protein)
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - 66796-54-1 (Pro-Opiomelanocortin)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/*deficiency
MH  - Cognition Disorders/genetics/pathology/physiopathology
MH  - Dendrites/*physiology/ultrastructure
MH  - Dentate Gyrus/*cytology/*growth & development
MH  - Gene Expression Regulation, Developmental/genetics
MH  - Green Fluorescent Proteins/biosynthesis/metabolism
MH  - Maze Learning/physiology
MH  - Mice
MH  - Mice, Transgenic
MH  - Pro-Opiomelanocortin/genetics
MH  - Reaction Time/genetics
MH  - Signal Transduction/*physiology
MH  - Synapses/*physiology
EDAT- 2008/11/19 09:00
MHDA- 2009/04/09 09:00
CRDT- 2008/11/19 09:00
PHST- 2008/04/29 00:00 [received]
PHST- 2008/08/25 00:00 [revised]
PHST- 2008/10/10 00:00 [accepted]
PHST- 2008/11/19 09:00 [pubmed]
PHST- 2009/04/09 09:00 [medline]
PHST- 2008/11/19 09:00 [entrez]
AID - S0014-4886(08)00400-7 [pii]
AID - 10.1016/j.expneurol.2008.10.009 [doi]
PST - ppublish
SO  - Exp Neurol. 2009 Jan;215(1):178-90. doi: 10.1016/j.expneurol.2008.10.009. Epub 
      2008 Oct 30.