PMID- 19015841
OWN - NLM
STAT- MEDLINE
DCOM- 20090303
LR  - 20211203
IS  - 1432-1211 (Electronic)
IS  - 0093-7711 (Linking)
VI  - 61
IP  - 1
DP  - 2009 Jan
TI  - Mouse to human comparative genetics reveals a novel immunoglobulin E-controlling 
      locus on Hsa8q12.
PG  - 15-25
LID - 10.1007/s00251-008-0343-x [doi]
AB  - Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against 
      common environmental allergens. It is often associated with development of 
      allergic diseases such as asthma, rhinitis, and dermatitis. Production of IgE is 
      influenced by genetic and environmental factors. In spite of progress in the 
      study of heredity of atopy, the genetic mechanisms of IgE regulation have not yet 
      been completely elucidated. The analysis of complex traits can benefit 
      considerably from integration of human and mouse genetics. Previously, we mapped 
      a mouse IgE-controlling locus Lmr9 on chromosome 4 to a segment of <9 Mb. In this 
      study, we tested levels of total IgE and 25 specific IgEs against inhalant and 
      food allergens in 67 Czech atopic families. In the position homologous to Lmr9 on 
      chromosome 8q12 marked by D8S285, we demonstrated a novel human IgE-controlling 
      locus exhibiting suggestive linkage to composite inhalant allergic sensitization 
      (limit of detection, LOD = 2.11, P = 0.0009) and to nine specific IgEs, with 
      maximum LOD (LOD = 2.42, P = 0.0004) to plantain. We also tested 16 markers at 
      previously reported chromosomal regions of atopy. Linkage to plant allergens 
      exceeding the LOD > 2.0 was detected at 5q33 (D5S1507, LOD = 2.11, P = 0.0009) 
      and 13q14 (D13S165, LOD = 2.74, P = 0.0002). The significant association with 
      plant allergens (quantitative and discrete traits) was found at 7p14 (D7S2250, 
      corrected P = 0.026) and 12q13 (D12S1298, corrected P = 0.043). Thus, the finding 
      of linkage on chromosome 8q12 shows precision and predictive power of mouse 
      models in the investigation of complex traits in humans. Our results also confirm 
      the role of loci at 5q33, 7p14, 12q14, and 13q13 in control of IgE.
FAU - Gusareva, Elena S
AU  - Gusareva ES
AD  - Department of Molecular and Cellular Immunology, Institute of Molecular Genetics, 
      Academy of Sciences of the Czech Republic, Videnska 1083, 142 20, Prague 4, Czech 
      Republic.
FAU - Havelkova, Helena
AU  - Havelkova H
FAU - Blazkova, Hana
AU  - Blazkova H
FAU - Kosarova, Marcela
AU  - Kosarova M
FAU - Kucera, Petr
AU  - Kucera P
FAU - Kral, Vlastimil
AU  - Kral V
FAU - Salyakina, Daria
AU  - Salyakina D
FAU - Muller-Myhsok, Bertram
AU  - Muller-Myhsok B
FAU - Lipoldova, Marie
AU  - Lipoldova M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081118
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Allergens/adverse effects/*immunology
MH  - Animals
MH  - Child
MH  - *Chromosome Mapping
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Czech Republic/epidemiology
MH  - Dermatitis, Atopic/ethnology/genetics/immunology
MH  - Epigenesis, Genetic/*genetics
MH  - Ethnicity/genetics
MH  - Female
MH  - Food Hypersensitivity/ethnology/genetics/immunology
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Hypersensitivity, Immediate/ethnology/*genetics
MH  - Immunoglobulin E/*biosynthesis/blood/immunology
MH  - Lod Score
MH  - Male
MH  - Mice/*genetics/immunology
MH  - Middle Aged
MH  - Quantitative Trait, Heritable
MH  - Respiratory Hypersensitivity/ethnology/genetics/immunology
MH  - Species Specificity
EDAT- 2008/11/19 09:00
MHDA- 2009/03/04 09:00
CRDT- 2008/11/19 09:00
PHST- 2008/05/29 00:00 [received]
PHST- 2008/10/23 00:00 [accepted]
PHST- 2008/11/19 09:00 [pubmed]
PHST- 2009/03/04 09:00 [medline]
PHST- 2008/11/19 09:00 [entrez]
AID - 10.1007/s00251-008-0343-x [doi]
PST - ppublish
SO  - Immunogenetics. 2009 Jan;61(1):15-25. doi: 10.1007/s00251-008-0343-x. Epub 2008 
      Nov 18.