PMID- 19016017
OWN - NLM
STAT- MEDLINE
DCOM- 20090324
LR  - 20181201
IS  - 0179-7158 (Print)
IS  - 0179-7158 (Linking)
VI  - 184
IP  - 11
DP  - 2008 Nov
TI  - Assessment of improved organ at risk sparing for advanced cervix carcinoma 
      utilizing precision radiotherapy techniques.
PG  - 586-91
LID - 10.1007/s00066-008-1872-9 [doi]
AB  - PURPOSE: To evaluate the potential benefit of proton therapy and photon based 
      intensity-modulated radiotherapy in comparison to 3-D conformal photon 
      radiotherapy (3D-CRT) in locally advanced cervix cancer. PATIENTS AND METHODS: In 
      five patients with advanced cervix cancer 3D-CRT (four-field box) was compared 
      with intensity modulated photon (IMXT) and proton therapy (IMPT) as well as 
      proton beam therapy (PT) based on passive scattering. Planning target volumes 
      (PTVs) included primary tumor and pelvic and para-aortic lymph nodes. Dose-volume 
      histograms (DVHs) were analyzed for the PTV and various organs at risk (OARs) 
      (rectal wall, bladder, small bowel, colon, femoral heads, and kidneys). In 
      addition dose conformity, dose inhomogeneity and overall volumes of 50% isodoses 
      were assessed. RESULTS: All plans were comparable concerning PTV parameters. 
      Large differences between photon and proton techniques were seen in volumes of 
      the 50% isodoses and conformity indices. DVH for colon and small bowel were 
      significantly improved with PT and IMPT compared to IMXT, with D(mean) reductions 
      of 50-80%. Doses to kidneys and femoral heads could also be substantially reduced 
      with PT and IMPT. Sparing of rectum and bladder was superior with protons as well 
      but less pronounced. CONCLUSION: Proton beam RT has significant potential to 
      improve treatment related side effects in the bowel compared to photon beam RT in 
      patients with advanced cervix carcinoma.
FAU - Georg, Dietmar
AU  - Georg D
AD  - Division Medical Radiation Physics, Department of Radiotherapy, Medical 
      University Vienna/AKH Vienna, Vienna, Austria. Dietmar.Georg@akhwien.at
FAU - Georg, Petra
AU  - Georg P
FAU - Hillbrand, Martin
AU  - Hillbrand M
FAU - Potter, Richard
AU  - Potter R
FAU - Mock, Ulrike
AU  - Mock U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081119
PL  - Germany
TA  - Strahlenther Onkol
JT  - Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et 
      al]
JID - 8603469
RN  - 0 (Protons)
SB  - IM
MH  - Abdomen/radiation effects
MH  - Female
MH  - Femur/radiation effects
MH  - Humans
MH  - Kidney/radiation effects
MH  - Lymphatic Metastasis/diagnostic imaging/pathology/*radiotherapy
MH  - Magnetic Resonance Imaging
MH  - Neoplasm Staging
MH  - Proton Therapy
MH  - Radiotherapy/*adverse effects/*methods
MH  - Radiotherapy Dosage
MH  - Rectum/radiation effects
MH  - Tomography, X-Ray Computed
MH  - Urinary Bladder/radiation effects
MH  - Uterine Cervical Neoplasms/pathology/*radiotherapy
EDAT- 2008/11/19 09:00
MHDA- 2009/03/25 09:00
CRDT- 2008/11/19 09:00
PHST- 2008/03/05 00:00 [received]
PHST- 2008/09/09 00:00 [accepted]
PHST- 2008/11/19 09:00 [pubmed]
PHST- 2009/03/25 09:00 [medline]
PHST- 2008/11/19 09:00 [entrez]
AID - 10.1007/s00066-008-1872-9 [doi]
PST - ppublish
SO  - Strahlenther Onkol. 2008 Nov;184(11):586-91. doi: 10.1007/s00066-008-1872-9. Epub 
      2008 Nov 19.