PMID- 19016800
OWN - NLM
STAT- MEDLINE
DCOM- 20090213
LR  - 20090108
IS  - 1365-2222 (Electronic)
IS  - 0954-7894 (Linking)
VI  - 39
IP  - 1
DP  - 2009 Jan
TI  - The danger within: endogenous danger signals, atopy and asthma.
PG  - 12-9
LID - 10.1111/j.1365-2222.2008.03118.x [doi]
AB  - In allergic asthmatics, airway inflammation is triggered by specific (inhalation 
      of allergen such as house dust mite allergen and pollen spores) or non-specific 
      triggers (such as air pollutants and viral infection). Most of these inhaled 
      particles are immunologically inert. Dendritic cells (DCs) are essential for 
      priming and T helper-2 differentiation of naive T cells towards aeroallergens. 
      Contamination of antigens with pattern-associated molecular patterns (PAMPs), 
      such as lipopolysaccharide (LPS), is required to activate DCs to mount an immune 
      response. Damage-associated molecular patterns (DAMPs), such as uric acid and 
      adenosine triphosphate (ATP), also contribute to the induction of inflammation by 
      activation and recruitment of various inflammatory cells. Compelling evidence 
      suggests that a tight collaboration between PAMPs and DAMPs is needed to start an 
      immune response to allergens. Several studies have recently demonstrated an 
      important role of endogenous danger signals at the inception and maintenance 
      phase of allergic disease. Further research into this area should focus on the 
      possible role of these factors in maintenance of chronic disease and induction of 
      airway remodelling.
FAU - Willart, M A M
AU  - Willart MA
AD  - Laboratory of Immunoregulation and Mucosal Immunity, Department of Pulmonary 
      Medicine, Ghent University, Ghent, Belgium. Monique.willart@ugent.be
FAU - Lambrecht, B N
AU  - Lambrecht BN
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20081030
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy 
      and Clinical Immunology
JID - 8906443
RN  - 0 (Antigens)
RN  - 0 (Lipopolysaccharides)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Antigens/*immunology
MH  - *Asthma/immunology/physiopathology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - *Hypersensitivity, Immediate/immunology/physiopathology
MH  - Inflammation/immunology/physiopathology
MH  - Lipopolysaccharides/*immunology
MH  - Lymphocyte Activation
MH  - Mice
MH  - T-Lymphocytes/immunology
MH  - Th2 Cells/immunology
RF  - 83
EDAT- 2008/11/20 09:00
MHDA- 2009/02/14 09:00
CRDT- 2008/11/20 09:00
PHST- 2008/11/20 09:00 [pubmed]
PHST- 2009/02/14 09:00 [medline]
PHST- 2008/11/20 09:00 [entrez]
AID - CEA3118 [pii]
AID - 10.1111/j.1365-2222.2008.03118.x [doi]
PST - ppublish
SO  - Clin Exp Allergy. 2009 Jan;39(1):12-9. doi: 10.1111/j.1365-2222.2008.03118.x. 
      Epub 2008 Oct 30.