PMID- 19017300
OWN - NLM
STAT- MEDLINE
DCOM- 20090306
LR  - 20090114
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 73
IP  - 1
DP  - 2009 Jan
TI  - Molecular mechanisms of HLA association with autoimmune diseases.
PG  - 1-8
LID - 10.1111/j.1399-0039.2008.01167.x [doi]
AB  - The association of human leukocyte antigen (HLA) molecules with many autoimmune 
      diseases has been long known. Yet, the molecular basis for these associations 
      remains unclear for most of these diseases because of the lack of identification 
      of a primary target autoantigen or autoantigens. In two frequent autoimmune 
      disorders, however, celiac disease and type 1 diabetes, recent progress in the 
      identification of immunogenic antigen epitopes and analysis of crystal structure 
      of particular HLA molecules in complex with disease-specific epitopes has allowed 
      for a better understanding of the molecular mechanisms underlying disease 
      association. In this review, these two diseases will be analyzed in detail to 
      show how HLA polymorphisms may directly contribute to susceptibility to, or 
      protection from, disease. Such analyses have significant interest in clinical 
      practice to identify at-risk individuals and elaborate new therapeutic strategies 
      aiming at inhibiting or preventing the autoimmune process.
FAU - Caillat-Zucman, S
AU  - Caillat-Zucman S
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM), U561, Hopital 
      St-Vincent de Paul, Paris, France. sophie.caillat@inserm.fr
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20081110
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Celiac Disease/*genetics/immunology
MH  - Diabetes Mellitus, Type 1/*genetics/immunology
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics/immunology
MH  - Haplotypes
MH  - Humans
MH  - Narcolepsy/*genetics/immunology
MH  - Polymorphism, Genetic/immunology
MH  - Spondylitis, Ankylosing/*genetics/immunology
RF  - 57
EDAT- 2008/11/20 09:00
MHDA- 2009/03/07 09:00
CRDT- 2008/11/20 09:00
PHST- 2008/11/20 09:00 [pubmed]
PHST- 2009/03/07 09:00 [medline]
PHST- 2008/11/20 09:00 [entrez]
AID - TAN1167 [pii]
AID - 10.1111/j.1399-0039.2008.01167.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2009 Jan;73(1):1-8. doi: 10.1111/j.1399-0039.2008.01167.x. Epub 
      2008 Nov 10.