PMID- 19017558
OWN - NLM
STAT- MEDLINE
DCOM- 20090414
LR  - 20081202
IS  - 0967-5868 (Print)
IS  - 0967-5868 (Linking)
VI  - 16
IP  - 1
DP  - 2009 Jan
TI  - Brain-derived neurotrophic factor concentrations in the cerebrospinal fluid of 
      patients with Parkinson's disease.
PG  - 90-3
LID - 10.1016/j.jocn.2008.03.010 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is widely expressed in the mammalian 
      brain. BDNF has been shown to promote differentiation and survival of all major 
      neuronal types affected in Parkinson's disease (PD). PD is a neurodegenerative 
      disorder of the central nervous system characterized pathologically by the loss 
      of dopaminergic neurons in the substantia nigra pars compacta. Cerebrospinal 
      fluid (CSF) contains factors that are important to the survival of dopaminergic 
      neurons. In this study CSF BDNF concentrations were measured in patients with PD 
      and in normal controls. A total of 48 CSF samples from patients with PD (n=24) 
      and controls (n=24) were studied. We used Western blot analysis and enzyme-linked 
      immunosorbent assay to study BDNF expression and concentration. The amount of 
      BDNF was clearly increased in CSF samples from patients with PD when compared 
      with normal CSF. BDNF could be involved in the pathophysiology of PD.
FAU - Salehi, Zivar
AU  - Salehi Z
AD  - Department of Biology, Faculty of Sciences, University of Guilan, Namjoo Street, 
      PO Box 1914, Rasht, Iran. geneticzs@yahoo.co.uk
FAU - Mashayekhi, Farhad
AU  - Mashayekhi F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081118
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/*cerebrospinal fluid
MH  - Case-Control Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*cerebrospinal fluid
EDAT- 2008/11/20 09:00
MHDA- 2009/04/15 09:00
CRDT- 2008/11/20 09:00
PHST- 2008/01/25 00:00 [received]
PHST- 2008/02/29 00:00 [revised]
PHST- 2008/03/05 00:00 [accepted]
PHST- 2008/11/20 09:00 [pubmed]
PHST- 2009/04/15 09:00 [medline]
PHST- 2008/11/20 09:00 [entrez]
AID - S0967-5868(08)00144-6 [pii]
AID - 10.1016/j.jocn.2008.03.010 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2009 Jan;16(1):90-3. doi: 10.1016/j.jocn.2008.03.010. Epub 2008 
      Nov 18.