PMID- 19017707
OWN - NLM
STAT- MEDLINE
DCOM- 20090506
LR  - 20151119
IS  - 1470-7926 (Electronic)
IS  - 1351-0711 (Linking)
VI  - 66
IP  - 4
DP  - 2009 Apr
TI  - Specific antibodies to diisocyanate and work-related respiratory symptoms in 
      apprentice car-painters.
PG  - 227-34
LID - 10.1136/oem.2007.038125 [doi]
AB  - BACKGROUND: Isocyanates are the main cause of occupational asthma in most 
      countries. Study of immunological markers of diisocyanate asthma may identify 
      individuals at risk. OBJECTIVES: (1) To study changes in specific antibodies to 
      hexamethylene diisocyanates (HDI); (2) to describe the incidence of work-related 
      respiratory symptoms in relation to changes in specific antibody levels. METHODS: 
      Prospective study in 385 apprentice car-painters during their 18 months of 
      training. Participants were assessed on entering and completing their training 
      using questionnaires, methacholine challenges and measurements of HDI-specific 
      immunoglobulin E (IgE), immunoglobulin G (IgG) and subclass 4 of IgG (IgG4) 
      antibodies. RESULTS: Complete data are available for 298 subjects. 13 subjects 
      (4.4%) reported >or=1 new work-related lower respiratory symptoms and 19 (6.4%), 
      >or=1 new work-related nasal symptoms. Increases in levels of specific IgE and 
      IgG above the 97th and 95th percentiles were significantly associated with 
      duration of exposure. Increase in specific IgG was inversely related to incidence 
      of work-related lower respiratory symptoms (OR = 0.001, 95% CI 0.000 to 0.09) 
      after adjusting for relevant covariates. The rise in specific IgG4 was 
      significantly greater in those who did not develop work-related nasal symptoms 
      (OR = 0.09, 95% CI 0.01 to 0.7). CONCLUSION: In this cohort of apprentice 
      car-painters, a small proportion show increases in HDI-specific IgG and IgE after 
      few months of exposure. Increases in specific IgG and IgG4 appear to have a 
      protective effect on the incidence of work-related lower and upper respiratory 
      symptoms, respectively. Assessment of specific antibodies to isocyanates may help 
      identify subjects at risk of developing symptoms.
FAU - Dragos, M
AU  - Dragos M
AD  - Department of Chest Medicine, Hopital du Sacre-Coeur, 5400 Gouin Blvd West, 
      Montreal, Quebec, Canada.
FAU - Jones, M
AU  - Jones M
FAU - Malo, J-L
AU  - Malo JL
FAU - Ghezzo, H
AU  - Ghezzo H
FAU - Gautrin, D
AU  - Gautrin D
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20081118
PL  - England
TA  - Occup Environ Med
JT  - Occupational and environmental medicine
JID - 9422759
RN  - 0 (Air Pollutants, Occupational)
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Cyanates)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Isocyanates)
RN  - 0I70A3I1UF (1,6-hexamethylene diisocyanate)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Air Pollutants, Occupational/*immunology
MH  - Antibodies, Anti-Idiotypic/*analysis/immunology
MH  - Automobiles
MH  - Canada/epidemiology
MH  - Cohort Studies
MH  - Cyanates/*immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*analysis/immunology
MH  - Immunoglobulin G/*analysis/immunology
MH  - Inservice Training
MH  - Isocyanates
MH  - Male
MH  - Occupational Diseases/diagnosis/epidemiology/immunology
MH  - Occupational Exposure/adverse effects
MH  - *Paint
MH  - Prospective Studies
MH  - Respiratory Tract Diseases/diagnosis/epidemiology/immunology
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2008/11/20 09:00
MHDA- 2009/05/07 09:00
CRDT- 2008/11/20 09:00
PHST- 2008/11/20 09:00 [pubmed]
PHST- 2009/05/07 09:00 [medline]
PHST- 2008/11/20 09:00 [entrez]
AID - oem.2007.038125 [pii]
AID - 10.1136/oem.2007.038125 [doi]
PST - ppublish
SO  - Occup Environ Med. 2009 Apr;66(4):227-34. doi: 10.1136/oem.2007.038125. Epub 2008 
      Nov 18.