PMID- 19019017
OWN - NLM
STAT- MEDLINE
DCOM- 20090414
LR  - 20090213
IS  - 1365-2982 (Electronic)
IS  - 1350-1925 (Linking)
VI  - 21
IP  - 2
DP  - 2009 Feb
TI  - Increased swallowing frequency in GORD is likely to be caused by perception of 
      reflux episodes.
PG  - 143-8
LID - 10.1111/j.1365-2982.2008.01197.x [doi]
AB  - Patients with gastro-oesophageal reflux disease (GORD) swallow air more 
      frequently and have more gas-containing reflux episodes than healthy controls. 
      One explanation for this phenomenon may be that GORD patients primarily swallow 
      more frequently and, as a consequence, have more swallow- or transient lower 
      oesophageal sphincter relaxation-associated reflux episodes. Another explanation 
      may be that GORD patients swallow more often in response to perception of reflux 
      episodes. The aim of this study was to differentiate between these two possible 
      mechanisms. In 34 patients with typical reflux symptoms oesophageal 24-h 
      pH-impedance monitoring was performed twice, once off and once on proton pump 
      inhibitor (PPI) therapy. The number of reflux episodes and number of swallows and 
      air swallows was evaluated. The symptom association probability (SAP) was used to 
      distinguish patients with a good relationship between symptoms and reflux 
      episodes (SAP+) from those who had not (SAP-). In both the SAP+ (n = 21) as SAP- 
      patients (n = 13), the acid exposure time decreased during PPI therapy. In the 
      SAP+ patients, the number of swallows decreased on PPI (829 +/- 85 off vs 701 +/- 
      79 on PPI, P < 0.05), whereas in the SAP- patients, the incidence of swallows 
      (802 +/- 93 off vs 814 +/- 69 on PPI, P = NS) was not influenced by the PPI 
      therapy. PPI therapy reduces the number of swallows in patients with a positive 
      SAP, but not in those with a negative SAP. This finding supports the hypothesis 
      that the increased incidence of swallows in GORD is brought about by responses to 
      perceived reflux events.
FAU - Hemmink, G J M
AU  - Hemmink GJ
AD  - Department of Gastroenterology, Sint Antonius Hospital, Nieuwegein, The 
      Netherlands. m.hemmink@antonius.net
FAU - Weusten, B L A M
AU  - Weusten BL
FAU - Bredenoord, A J
AU  - Bredenoord AJ
FAU - Timmer, R
AU  - Timmer R
FAU - Smout, A J P M
AU  - Smout AJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081006
PL  - England
TA  - Neurogastroenterol Motil
JT  - Neurogastroenterology and motility
JID - 9432572
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - *Deglutition
MH  - Esophageal pH Monitoring
MH  - Gastroesophageal Reflux/drug therapy/pathology/*physiopathology
MH  - Humans
MH  - Proton Pump Inhibitors/therapeutic use
EDAT- 2008/11/21 09:00
MHDA- 2009/04/15 09:00
CRDT- 2008/11/21 09:00
PHST- 2008/11/21 09:00 [pubmed]
PHST- 2009/04/15 09:00 [medline]
PHST- 2008/11/21 09:00 [entrez]
AID - NMO1197 [pii]
AID - 10.1111/j.1365-2982.2008.01197.x [doi]
PST - ppublish
SO  - Neurogastroenterol Motil. 2009 Feb;21(2):143-8. doi: 
      10.1111/j.1365-2982.2008.01197.x. Epub 2008 Oct 6.