PMID- 19019896
OWN - NLM
STAT- MEDLINE
DCOM- 20091117
LR  - 20091013
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 68
IP  - 11
DP  - 2009 Nov
TI  - Genetic polymorphisms of the matrix metalloproteinase-3 (MMP-3) and tissue 
      inhibitors of matrix metalloproteinases-1 (TIMP-1) modulate the development of 
      ankylosing spondylitis.
PG  - 1781-6
LID - 10.1136/ard.2008.099481 [doi]
AB  - BACKGROUND: The aetiology of ankylosing spondylitis (AS) remains unclear. 
      Inflammation progresses to fibrosis and calcification of the spine and sacroiliac 
      joints in AS development. Fibrosis results from excessive accumulations of the 
      extracellular matrix (ECM). ECM turnover depends on the balance between matrix 
      metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). OBJECTIVE: To 
      evaluate the effects of the MMP-3 -1171 and TIMP-1 372 T>C polymorphisms on the 
      modified risk of AS. METHODS: Genotypes of 241 patients with AS and 241 controls 
      were identified by PCR. Disease activity and functional status were assessed by 
      the Bath Ankylosing Spondylitis Activity Index (BASDAI), the Bath Ankylosing 
      Spondylitis Functional Index (BASFI) and the Bath Ankylosing Spondylitis Global 
      (BAS-G) Score. RESULTS: MMP-3 6A/6A carriers had a 2.41-fold (95% confidence 
      interval (CI) 1.55 to 3.74) increased risk of AS compared with 6A/5A and 5A/5A 
      carriers. TIMP-1 C alleles had a greater risk of AS, but this was not significant 
      (odds ratio (OR) = 1.28, 95% CI 0.92 to 1.77). Pairwise analysis of the 
      MMP-3/TIMP-1 alleles showed that 6A/C (OR = 3.23, 95% CI 1.50 to 6.95) and 6A/T 
      (OR = 2.55, 95% CI 1.17 to 5.54) had a significantly greater risk of AS than the 
      5A/T alleles. After adjustment for the effects of age, gender and disease 
      duration, the MMP-3/TIMP-1 5A/T alleles had the lowest BASDAI (p = 0.02), BASFI 
      (p = 0.05) and BAS-G (p = 0.02) among all MMP-3/TIMP-1 alleles. CONCLUSION: The 
      findings highlight the importance of the MMP-3 and TIMP-1 genes as crucial 
      elements in AS development.
FAU - Wei, J C-C
AU  - Wei JC
AD  - Department of Medicine, Chung Shan Medical University, Taichung, Taiwan.
FAU - Lee, H-S
AU  - Lee HS
FAU - Chen, W-C
AU  - Chen WC
FAU - Shiu, L-J
AU  - Shiu LJ
FAU - Yang, S-F
AU  - Yang SF
FAU - Wong, R-H
AU  - Wong RH
LA  - eng
PT  - Journal Article
DEP - 20081119
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Severity of Illness Index
MH  - Spondylitis, Ankylosing/*genetics
MH  - Tissue Inhibitor of Metalloproteinase-1/*genetics
MH  - Young Adult
EDAT- 2008/11/21 09:00
MHDA- 2009/11/18 06:00
CRDT- 2008/11/21 09:00
PHST- 2008/11/21 09:00 [pubmed]
PHST- 2009/11/18 06:00 [medline]
PHST- 2008/11/21 09:00 [entrez]
AID - ard.2008.099481 [pii]
AID - 10.1136/ard.2008.099481 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2009 Nov;68(11):1781-6. doi: 10.1136/ard.2008.099481. Epub 2008 
      Nov 19.