PMID- 19021051
OWN - NLM
STAT- MEDLINE
DCOM- 20090107
LR  - 20210103
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 49
IP  - 11
DP  - 2008 Nov
TI  - Elevated pretreatment interleukin-10 serum level is an International Prognostic 
      Score (IPS)-independent risk factor for early treatment failure in advanced stage 
      Hodgkin lymphoma.
PG  - 2091-8
LID - 10.1080/10428190802441339 [doi]
AB  - Early treatment failure is still a clinical challenge despite high cure rates in 
      Hodgkin lymphoma (HL) patients. To identify the biological risk factors 
      predicting early treatment failure, we performed a retrospective case-control 
      study. Forty-seven pretherapeutic serum samples were available from 47 advanced 
      stage HL patients with early treatment failure and from 47 matched controls in 
      complete remission. All patients were treated within German Hodgkin Study Group 
      phase 3 trials. Matching was done according to treatment, stage, age, gender, 
      International Prognostic Score (IPS) and histological subtype. Pretreatment serum 
      levels of 30 cytokines, chemokines and soluble receptors were determined using 
      immunoassays and flow cytometer based cytometric bead arrays. Only interleukin-10 
      serum levels were significantly associated with early treatment failure after 
      statistical correction for multitesting (paired-sign test, p = 0.0008). In 
      summary, pretherapeutic interleukin-10 levels are associated with early treatment 
      failure within 12 months after the end of treatment in advanced stage HL 
      independently from known clinical factors such as age or IPS.
FAU - Rautert, Roger
AU  - Rautert R
AD  - Department of Internal Medicine I, University Hospital of Cologne, Cologne, 
      Germany.
FAU - Schinkothe, Timo
AU  - Schinkothe T
FAU - Franklin, Jeremy
AU  - Franklin J
FAU - Weihrauch, Martin
AU  - Weihrauch M
FAU - Boll, Boris
AU  - Boll B
FAU - Pogge, Elke
AU  - Pogge E
FAU - Bredenfeld, Henning
AU  - Bredenfeld H
FAU - Engert, Andreas
AU  - Engert A
FAU - Diehl, Volker
AU  - Diehl V
FAU - Re, Daniel
AU  - Re D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
CIN - Leuk Lymphoma. 2008 Nov;49(11):2031-2. PMID: 19021042
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Chemokines/blood
MH  - Cytokines/blood
MH  - Female
MH  - Hodgkin Disease/*diagnosis/pathology
MH  - Humans
MH  - Interleukin-10/*blood/immunology/metabolism
MH  - Male
MH  - Middle Aged
MH  - *Predictive Value of Tests
MH  - Prognosis
MH  - Retrospective Studies
MH  - Treatment Failure
EDAT- 2008/11/21 09:00
MHDA- 2009/01/08 09:00
CRDT- 2008/11/21 09:00
PHST- 2008/11/21 09:00 [pubmed]
PHST- 2009/01/08 09:00 [medline]
PHST- 2008/11/21 09:00 [entrez]
AID - 905683002 [pii]
AID - 10.1080/10428190802441339 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2008 Nov;49(11):2091-8. doi: 10.1080/10428190802441339.