PMID- 19021599
OWN - NLM
STAT- MEDLINE
DCOM- 20091106
LR  - 20090811
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 87
IP  - 5
DP  - 2009 Aug
TI  - Anti-aquaporin-4 antibody-positive optic neuritis.
PG  - 562-6
LID - 10.1111/j.1755-3768.2008.01259.x [doi]
AB  - PURPOSE: It has recently been reported that the anti-aquaporin-4 antibody 
      (AQP4-Ab) can be a specific marker of neuromyelitis optica. We present three 
      cases of optic neuritis (ON) where the patients tested positive for AQP4-Ab, but 
      showed no neurological signs. METHODS: Sera were obtained from 32 Japanese 
      patients with ON and no other neurological abnormalities (mean age 46 +/- 20 
      years). AQP4-Ab was detected by indirect immunofluorescence staining using 
      human-AQP4-transfected HEK 293 cells. RESULTS: AQP4-Ab was positive in three 
      female patients (aged 9, 64 and 82 years). Their illness was characterized by 
      bilateral severe optic nerve involvement, insufficient visual recovery, and 
      autoimmune abnormalities (such as positive antinuclear antibody). Two of these 
      patients experienced recurrent episodes of ON. In at least two episodes, the 
      intracranial portion of the optic nerve showed significant inflammation on 
      magnetic resonance imaging. CONCLUSIONS: These cases indicate that some ON 
      patients have an immunological pathogenesis similar to that seen in neuromyelitis 
      optica. In addition, examination for AQP4-Ab positivity in the initial phase of 
      ON is important in predicting the prognosis, including the possibility of the 
      development of transverse myelitis.
FAU - Takagi, Mineo
AU  - Takagi M
AD  - Niigata University, Japan. mtakagi@med.niigata-u.ac.jp
FAU - Tanaka, Keiko
AU  - Tanaka K
FAU - Suzuki, Tone
AU  - Suzuki T
FAU - Miki, Atsushi
AU  - Miki A
FAU - Nishizawa, Masatoyo
AU  - Nishizawa M
FAU - Abe, Haruki
AU  - Abe H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081119
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
RN  - 0 (Aquaporin 4)
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Aged, 80 and over
MH  - Aquaporin 4/*immunology
MH  - Autoantibodies/*blood
MH  - Child
MH  - Female
MH  - Fluorescent Antibody Technique, Indirect
MH  - Follow-Up Studies
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Middle Aged
MH  - Optic Neuritis/diagnosis/*immunology/physiopathology
MH  - Severity of Illness Index
MH  - Visual Acuity
EDAT- 2008/11/22 09:00
MHDA- 2009/11/07 06:00
CRDT- 2008/11/22 09:00
PHST- 2008/11/22 09:00 [pubmed]
PHST- 2009/11/07 06:00 [medline]
PHST- 2008/11/22 09:00 [entrez]
AID - AOS1259 [pii]
AID - 10.1111/j.1755-3768.2008.01259.x [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2009 Aug;87(5):562-6. doi: 10.1111/j.1755-3768.2008.01259.x. 
      Epub 2008 Nov 19.