PMID- 19022486
OWN - NLM
STAT- MEDLINE
DCOM- 20090305
LR  - 20090202
IS  - 1527-9995 (Electronic)
IS  - 0090-4295 (Linking)
VI  - 73
IP  - 2
DP  - 2009 Feb
TI  - Prognostic significance of nondiagnostic molecular changes in urine detected by 
      UroVysion fluorescence in situ hybridization during surveillance for bladder 
      cancer.
PG  - 347-50
LID - 10.1016/j.urology.2008.09.042 [doi]
AB  - OBJECTIVES: To determine the outcomes for patients with nondiagnostic 
      fluorescence in situ hybridization (FISH) (ie, < 4 gains of chromosomes 3, 7, or 
      17 in < or = 3 cells). FISH detects urothelial carcinoma and is especially 
      beneficial in patients with negative or atypical urine cytology findings. A 
      positive result is defined as a gain of > or = 2 chromosomes (3, 7, or 17) in 4 
      cells, isolated loss of 9p21 in 12 cells, or isolated gains of only 1 chromosome 
      in > or = 10% of cells. Most FISH-positive patients will develop recurrent 
      urothelial carcinoma within 1 year. METHODS: We compared the data from 149 
      patients with a nondiagnostic FISH result and > or = 30 months of follow-up with 
      the data from patients with a negative FISH result from the same period. The time 
      to conversion to a positive FISH result or the development of a bladder tumor was 
      recorded. RESULTS: Patients with nondiagnostic FISH results had significantly 
      greater rates of progression to positive FISH findings or the development of a 
      bladder tumor than did patients with negative FISH findings. Most progression 
      occurred within 1 year. Patients with nondiagnostic FISH results and concurrent 
      negative cytology and cystoscopy had a very low risk of developing recurrent 
      disease, similar to that found with truly negative FISH results. CONCLUSIONS: 
      Nondiagnostic FISH results are related to a greater risk of progression to 
      positive FISH results and tumor recurrence than those with negative FISH 
      findings. However, after controlling for negative cytologic and cystoscopic 
      status, a nondiagnostic FISH result does not appear to be an independent 
      predictor of disease recurrence, and aggressive investigation is not warranted.
FAU - Nguyen, Carvell T
AU  - Nguyen CT
AD  - Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 
      44195, USA.
FAU - Litt, David B
AU  - Litt DB
FAU - Dolar, Sandra E
AU  - Dolar SE
FAU - Ulchaker, James C
AU  - Ulchaker JC
FAU - Jones, J Stephen
AU  - Jones JS
FAU - Brainard, Jennifer A
AU  - Brainard JA
LA  - eng
PT  - Journal Article
DEP - 20081120
PL  - United States
TA  - Urology
JT  - Urology
JID - 0366151
SB  - IM
MH  - Aged
MH  - Carcinoma, Transitional Cell/*urine
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Male
MH  - Neoplasm Recurrence, Local/*urine
MH  - Population Surveillance
MH  - Prognosis
MH  - Risk Assessment
MH  - Urinary Bladder Neoplasms/*urine
EDAT- 2008/11/22 09:00
MHDA- 2009/03/06 09:00
CRDT- 2008/11/22 09:00
PHST- 2008/07/09 00:00 [received]
PHST- 2008/08/21 00:00 [revised]
PHST- 2008/09/20 00:00 [accepted]
PHST- 2008/11/22 09:00 [pubmed]
PHST- 2009/03/06 09:00 [medline]
PHST- 2008/11/22 09:00 [entrez]
AID - S0090-4295(08)01669-5 [pii]
AID - 10.1016/j.urology.2008.09.042 [doi]
PST - ppublish
SO  - Urology. 2009 Feb;73(2):347-50. doi: 10.1016/j.urology.2008.09.042. Epub 2008 Nov 
      20.