PMID- 19023378
OWN - NLM
STAT- MEDLINE
DCOM- 20090123
LR  - 20211020
IS  - 1539-4522 (Electronic)
IS  - 0003-6935 (Print)
IS  - 1559-128X (Linking)
VI  - 47
IP  - 33
DP  - 2008 Nov 20
TI  - Experimental confirmation of potential swept source optical coherence tomography 
      performance limitations.
PG  - 6151-8
AB  - Optical coherence tomography (OCT) has demonstrated considerable potential for a 
      wide range of medical applications. Initial work was done in the time domain OCT 
      (TD-OCT) approach, but recent interest has been generated with spectral domain 
      OCT (SD-OCT) approaches. While SD-OCT offers higher data acquisition rates and no 
      movable parts, we recently pointed out theoretical inferior aspects to its 
      performance relative to TD-OCT. In this paper we focus on specific limitations of 
      swept source OCT (SS-OCT), as this is the more versatile of the two SD-OCT 
      embodiments. We present experimental evidence of reduced imaging penetration, 
      increased low frequency noise, higher multiple scattering (which can be worsened 
      still via aliasing), increased need to control the distance from the sample, and 
      saturation of central bandwidth frequencies. We conclude that for scenarios where 
      the dynamic range is relatively low (e.g., retina), the distance from the sample 
      is relatively constant, or high acquisition rates are needed, SS-OCT has a role. 
      However, when penetration remains important in the setting of a relatively high 
      dynamic range, acquisition rates above video rate are not needed, or the distance 
      to the tissue is not constant, TD-OCT may be the superior approach.
FAU - Zheng, Kathy
AU  - Zheng K
AD  - Center for Optical Coherence Tomography and Optical Physics, Department of 
      Orthopedic Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA.
FAU - Liu, Bin
AU  - Liu B
FAU - Huang, Chuanyong
AU  - Huang C
FAU - Brezinski, Mark E
AU  - Brezinski ME
LA  - eng
GR  - R01 HL55686/HL/NHLBI NIH HHS/United States
GR  - R01 AR44812/AR/NIAMS NIH HHS/United States
GR  - R01 AR046996/AR/NIAMS NIH HHS/United States
GR  - R01 EB002638-07/EB/NIBIB NIH HHS/United States
GR  - R01 HL055686/HL/NHLBI NIH HHS/United States
GR  - R01 EB02638/HL63953/EB/NIBIB NIH HHS/United States
GR  - R01 EB000419/EB/NIBIB NIH HHS/United States
GR  - R01 AR046996-07/AR/NIAMS NIH HHS/United States
GR  - R01 AR044812/AR/NIAMS NIH HHS/United States
GR  - R01 EB002638/EB/NIBIB NIH HHS/United States
GR  - R01 AR044812-10/AR/NIAMS NIH HHS/United States
GR  - R01 AR46996/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Appl Opt
JT  - Applied optics
JID - 0247660
SB  - IM
MH  - *Algorithms
MH  - Animals
MH  - Cattle
MH  - Image Enhancement/methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Imaging, Three-Dimensional/*methods
MH  - Lighting/*methods
MH  - Menisci, Tibial/*cytology
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Tomography, Optical Coherence/*methods
PMC - PMC2640108
MID - NIHMS89535
EDAT- 2008/11/22 09:00
MHDA- 2009/01/24 09:00
PMCR- 2009/02/11
CRDT- 2008/11/22 09:00
PHST- 2008/11/22 09:00 [pubmed]
PHST- 2009/01/24 09:00 [medline]
PHST- 2008/11/22 09:00 [entrez]
PHST- 2009/02/11 00:00 [pmc-release]
AID - 174423 [pii]
AID - 10.1364/ao.47.006151 [doi]
PST - ppublish
SO  - Appl Opt. 2008 Nov 20;47(33):6151-8. doi: 10.1364/ao.47.006151.