PMID- 19023542
OWN - NLM
STAT- MEDLINE
DCOM- 20090105
LR  - 20151119
IS  - 0253-6269 (Print)
IS  - 0253-6269 (Linking)
VI  - 31
IP  - 11
DP  - 2008 Nov
TI  - Neuroprotective effects of chronic hesperetin administration in mice.
PG  - 1457-62
LID - 10.1007/s12272-001-2130-1 [doi]
AB  - Flavonoids are considered therapeutic agents in neurodegenerative disease because 
      of their neuroprotective activity. This study investigated the neuroprotective 
      effects of hesperetin in the brains of mice administered hesperetin at 10 or 50 
      mg/kg body weight (BW) for five weeks. Hesperetin inhibited biomarkers of 
      oxidative stress, such as the level of thiobarbituric acid-reactive substance 
      (TBARS) and carbonyl content, although there was a significant reduction at the 
      higher dose of hesperetin. Moreover, at the higher dose, hesperetin significantly 
      activated the catalase and total superoxide dismutase (SOD) activities. The same 
      patterns were observed in the protein expression, and the expression of CuZn-SOD 
      was more pronounced than that of Mn-SOD. The reduced glutathione (GSH)/oxidized 
      glutathione (GSSG) ratio was increased significantly in a dose-dependent manner, 
      as well as the glutathione peroxidase (GSH-px) and glutathione reductase (GR) 
      activities. Moreover, hesperetin did not induce apoptosis, even at the higher 
      dose, as evidenced by caspase-3 expression and its activity. Based on these 
      results, hesperetin may have a neuroprotective effect via the inhibition of 
      oxidative damage, together with activation of the antioxidant enzyme system.
FAU - Choi, Eun Jeong
AU  - Choi EJ
AD  - Cancer Research Institute, The Catholic University of Korea, Seoul 137-040, 
      Korea.
FAU - Ahn, Woong Shick
AU  - Ahn WS
LA  - eng
PT  - Journal Article
DEP - 20081121
PL  - Korea (South)
TA  - Arch Pharm Res
JT  - Archives of pharmacal research
JID - 8000036
RN  - 0 (Antioxidants)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - E750O06Y6O (Hesperidin)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - GAN16C9B8O (Glutathione)
RN  - Q9Q3D557F1 (hesperetin)
SB  - IM
MH  - Animals
MH  - Antioxidants/pharmacology
MH  - Blotting, Western
MH  - Brain Chemistry/drug effects
MH  - Catalase/metabolism
MH  - Female
MH  - Glutathione/metabolism
MH  - Hesperidin/*pharmacology
MH  - Mice
MH  - Mice, Inbred ICR
MH  - *Neuroprotective Agents
MH  - Oxidative Stress/drug effects
MH  - Protein Carbonylation/drug effects
MH  - Superoxide Dismutase/metabolism
MH  - Thiobarbituric Acid Reactive Substances/metabolism
EDAT- 2008/11/22 09:00
MHDA- 2009/01/06 09:00
CRDT- 2008/11/22 09:00
PHST- 2008/08/14 00:00 [received]
PHST- 2008/10/21 00:00 [accepted]
PHST- 2008/10/16 00:00 [revised]
PHST- 2008/11/22 09:00 [pubmed]
PHST- 2009/01/06 09:00 [medline]
PHST- 2008/11/22 09:00 [entrez]
AID - 10.1007/s12272-001-2130-1 [doi]
PST - ppublish
SO  - Arch Pharm Res. 2008 Nov;31(11):1457-62. doi: 10.1007/s12272-001-2130-1. Epub 
      2008 Nov 21.