PMID- 19024211
OWN - NLM
STAT- MEDLINE
DCOM- 20081216
LR  - 20131121
IS  - 1128-3602 (Print)
IS  - 1128-3602 (Linking)
VI  - 12
IP  - 5
DP  - 2008 Sep-Oct
TI  - Effects on rat sexual behaviour of acute MDMA (ecstasy) alone or in combination 
      with loud music.
PG  - 285-92
AB  - The effects on sexual behaviour of acute low doses of 
      methylendioxymethamphetamine (MDMA) (0.3, 1, 3 mg/kg/i.p.), alone or in 
      combination with exposure to loud music (1 h stimulation), were investigated in 
      Wistar rats. Results indicate that acute MDMA, at dose of 3 mg/kg, notably 
      impaired copulatory behavior of sexually experienced male rats. In particular, 
      MDMA-exposed animals exhibited a significant increase in intromission and 
      ejaculation latencies as well as a significant decrease in percentage of rats 
      displaying copulatory activity (one intromission at least). Surprisingly, one 
      hour exposure to loud music, which per se resulted ineffective, antagonized the 
      suppressive effect of MDMA by increasing the percent of animals displaying sexual 
      activity. However, combined treatment of MDMA and music stimulation did not fully 
      restore normal sexual behavior as the animals reaching ejaculation still showed a 
      marked reduction of copulatory efficiency. These findings demonstrate that the 
      systemic administration of a single low dose of MDMA, alone or in combination 
      with loud music, which is commonly present in certain environments such as rave 
      parties, notably impairs copulatory activity of male rats.
FAU - Cagiano, R
AU  - Cagiano R
AD  - Department of Pharmacology and Human Physiology, Faculty of Medicine, University 
      of Bari, Bari, Italy. r.cagiano@farmacol.uniba.it
FAU - Bera, I
AU  - Bera I
FAU - Sabatini, R
AU  - Sabatini R
FAU - Flace, P
AU  - Flace P
FAU - Vermesan, D
AU  - Vermesan D
FAU - Vermesan, H
AU  - Vermesan H
FAU - Dragulescu, S I
AU  - Dragulescu SI
FAU - Bottalico, L
AU  - Bottalico L
FAU - Santacroce, L
AU  - Santacroce L
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Copulation/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Hallucinogens/*pharmacology
MH  - Male
MH  - Music/*psychology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Sexual Behavior, Animal/*drug effects
MH  - Vocalization, Animal/drug effects
EDAT- 2008/11/26 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/11/26 09:00
PHST- 2008/11/26 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/11/26 09:00 [entrez]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2008 Sep-Oct;12(5):285-92.