PMID- 19025720
OWN - NLM
STAT- MEDLINE
DCOM- 20090903
LR  - 20151119
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 101
IP  - 12
DP  - 2009 Jun
TI  - The effect of apoE genotype and sex on ApoE plasma concentration is determined by 
      dietary fat in healthy subjects.
PG  - 1745-52
LID - 10.1017/S0007114508111515 [doi]
AB  - The interindividual variation in ApoE plasma concentration is considerable, 
      mainly determined by apoE genotype and sex. However, a large amount of 
      variability remains unexplained by these factors. We have evaluated whether the 
      quantity and quality of dietary fat interacts with the apoE genotype and sex 
      modifying ApoE plasma levels in young healthy subjects. Eighty-four volunteers 
      (sixty-six apoE3/3, eight apoE4/3 and ten apoE3/2) were subjected to three 
      dietary periods, each lasting 4 weeks. The first was a SFA-enriched diet (38 % 
      fat and 20 % SFA), which was followed by a carbohydrate (CHO)-rich diet (30 % 
      fat, < 10 % SFA and 55 % carbohydrate) or a MUFA-rich diet (38 % fat and 22 % 
      MUFA) following a randomised crossover design. apoE2 carriers have the highest 
      ApoE levels, whereas apoE4 individuals show the lowest concentration after the 
      SFA, CHO and MUFA diets. Women had significantly higher ApoE concentration than 
      men only after the consumption of the SFA diet. The SFA diet increased the ApoE 
      plasma concentration when compared with the CHO- and MUFA-rich diets in women, 
      but not in men. In women, but not in men, the shift from the SFA- to CHO- or 
      MUFA-rich diets significantly decreased the ApoE concentration in apoE3/2 and 
      apoE3/3 subjects, whereas no differences were observed in women with the apoE4/3 
      genotype. Sex and apoE genotype determine ApoE plasma levels; however, this 
      effect is dependent on dietary fat.
FAU - Moreno, Juan Antonio
AU  - Moreno JA
AD  - Lipids and Atherosclerosis Research Unit, Hospital Universitario Reina Sofia, 
      Avda Menendez Pidal, s/n. 14004, Cordoba, Spain.
FAU - Perez-Jimenez, Francisco
AU  - Perez-Jimenez F
FAU - Moreno-Luna, Rafael
AU  - Moreno-Luna R
FAU - Perez-Martinez, Pablo
AU  - Perez-Martinez P
FAU - Fuentes-Jimenez, Francisco
AU  - Fuentes-Jimenez F
FAU - Marin, Carmen
AU  - Marin C
FAU - Portugal, Henri
AU  - Portugal H
FAU - Lairon, Denis
AU  - Lairon D
FAU - Lopez-Miranda, Jose
AU  - Lopez-Miranda J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081124
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Apolipoprotein A-I)
RN  - 0 (Apolipoprotein E2)
RN  - 0 (Apolipoprotein E3)
RN  - 0 (Apolipoprotein E4)
RN  - 0 (Apolipoproteins B)
RN  - 0 (Apolipoproteins E)
RN  - 0 (Biomarkers)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids, Monounsaturated)
RN  - 0 (Fatty Acids, Volatile)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Apolipoprotein A-I/blood
MH  - Apolipoprotein E2/genetics
MH  - Apolipoprotein E3/genetics
MH  - Apolipoprotein E4/genetics
MH  - Apolipoproteins B/blood
MH  - Apolipoproteins E/*blood/*genetics
MH  - Biomarkers/blood
MH  - Cholesterol/blood
MH  - Cholesterol, HDL/blood
MH  - Cholesterol, LDL/blood
MH  - Dietary Carbohydrates/administration & dosage
MH  - Dietary Fats/*administration & dosage
MH  - Fatty Acids, Monounsaturated/administration & dosage
MH  - Fatty Acids, Volatile/administration & dosage
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Sex Factors
MH  - Triglycerides/blood
MH  - Young Adult
EDAT- 2008/11/26 09:00
MHDA- 2009/09/04 06:00
CRDT- 2008/11/26 09:00
PHST- 2008/11/26 09:00 [pubmed]
PHST- 2009/09/04 06:00 [medline]
PHST- 2008/11/26 09:00 [entrez]
AID - S0007114508111515 [pii]
AID - 10.1017/S0007114508111515 [doi]
PST - ppublish
SO  - Br J Nutr. 2009 Jun;101(12):1745-52. doi: 10.1017/S0007114508111515. Epub 2008 
      Nov 24.