PMID- 19026602
OWN - NLM
STAT- MEDLINE
DCOM- 20090219
LR  - 20211028
IS  - 1570-0232 (Print)
IS  - 1570-0232 (Linking)
VI  - 876
IP  - 2
DP  - 2008 Dec 15
TI  - A validated gas chromatographic-electron impact ionization mass spectrometric 
      method for methamphetamine, methylenedioxymethamphetamine (MDMA), and metabolites 
      in mouse plasma and brain.
PG  - 266-76
LID - 10.1016/j.jchromb.2008.11.001 [doi]
AB  - A method was developed and fully validated for simultaneous quantification of 
      methamphetamine (MAMP), amphetamine, hydroxy-methamphetamine, 
      methylenedioxymethamphetamine (MDMA, ecstasy), methylenedioxyamphetamine, 
      3-hydroxy-4-methoxy-methamphetamine, and 3-hydroxy-4-methoxy-amphetamine in 100 
      microL mouse plasma and 7.5mg brain. Solid phase extraction and gas 
      chromatography-electron impact ionization mass spectrometry in selected-ion 
      monitoring mode achieved plasma linear ranges of 10-20 to 20,000 ng/mL and 
      0.1-0.2 to 200 ng/mg in brain. Recoveries were greater than 91%, bias 
      92.3-110.4%, and imprecision less than 5.3% coefficient of variation. This method 
      was used for measuring MAMP and MDMA and metabolites in plasma and brain during 
      mouse neurotoxicity studies.
FAU - Scheidweiler, Karl B
AU  - Scheidweiler KB
AD  - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on 
      Drug Abuse, National Institutes of Health, Biomedical Research Center, 251 
      Bayview Boulevard, Baltimore, MD 21224, USA.
FAU - Barnes, Allan J
AU  - Barnes AJ
FAU - Huestis, Marilyn A
AU  - Huestis MA
LA  - eng
GR  - Z01 DA000506-01/ImNIH/Intramural NIH HHS/United States
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20081107
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
RN  - 44RAL3456C (Methamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Brain Chemistry
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Humans
MH  - Hydrolysis
MH  - Male
MH  - Methamphetamine/*analysis/*blood/metabolism
MH  - Mice
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*analysis/*blood/metabolism
MH  - Sensitivity and Specificity
MH  - Spectrometry, Mass, Electrospray Ionization/methods
PMC - PMC2607242
MID - NIHMS81873
EDAT- 2008/11/26 09:00
MHDA- 2009/02/20 09:00
PMCR- 2009/12/15
CRDT- 2008/11/26 09:00
PHST- 2008/07/16 00:00 [received]
PHST- 2008/10/27 00:00 [revised]
PHST- 2008/11/02 00:00 [accepted]
PHST- 2008/11/26 09:00 [pubmed]
PHST- 2009/02/20 09:00 [medline]
PHST- 2008/11/26 09:00 [entrez]
PHST- 2009/12/15 00:00 [pmc-release]
AID - S1570-0232(08)00819-2 [pii]
AID - 10.1016/j.jchromb.2008.11.001 [doi]
PST - ppublish
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Dec 15;876(2):266-76. doi: 
      10.1016/j.jchromb.2008.11.001. Epub 2008 Nov 7.