PMID- 19026702
OWN - NLM
STAT- MEDLINE
DCOM- 20090512
LR  - 20181201
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 70
IP  - 1
DP  - 2009 Jan
TI  - Interleukin-21 stimulates B-cell immunoglobulin E synthesis in human beings 
      concomitantly with activation-induced cytidine deaminase expression and 
      differentiation into plasma cells.
PG  - 35-40
LID - 10.1016/j.humimm.2008.10.021 [doi]
AB  - Interleukin (IL)-21 downregulates immunoglobulin E (IgE) production in murine 
      systems by inhibiting germline epsilon transcription in IL-4-stimulated B cells. 
      We here sought to clarify the function of IL-21 in human B-cell IgE synthesis. 
      IL-21 dramatically enhanced IgE production by human mononuclear cells, or 
      purified total, naive, or memory B cells in the presence of IL-4 plus anti-CD40 
      mAb cross-linked with CD32-transfectants, and the production was strengthened 
      with further addition of IL-10. It was concomitant to the enhancement of 
      activation-induced cytidine deaminase (AID) mRNA expression, but no increase of 
      germline epsilon transcription. We also observed that IL-21 promoted B-cell 
      differentiation into plasma cells with increase of B-lymphocyte-induced 
      maturation protein-1 (Blimp-1), but not X-box binding protein 1 (XBP-1), which 
      was further accentuated by co-stimulation with IL-4 plus CD40 signaling. Thus, 
      IL-21 is a strong inducer of IgE production in human beings concomitantly with 
      AID expression and the differentiation into plasma cells. Our data suggest that 
      IL-21 plays an important role in occurrence and the treatment of allergic 
      disorders.
FAU - Kobayashi, Shinji
AU  - Kobayashi S
AD  - Department of Infection and Host Defense, Shinshu University, Matsumoto, Japan.
FAU - Haruo, Nagumo
AU  - Haruo N
FAU - Sugane, Kazuo
AU  - Sugane K
FAU - Ochs, Hans D
AU  - Ochs HD
FAU - Agematsu, Kazunaga
AU  - Agematsu K
LA  - eng
PT  - Journal Article
DEP - 20081119
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (CD40 Antigens)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Interleukins)
RN  - 0 (Receptors, IgG)
RN  - 0 (Regulatory Factor X Transcription Factors)
RN  - 0 (Repressor Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (X-Box Binding Protein 1)
RN  - 0 (XBP1 protein, human)
RN  - 130068-27-8 (Interleukin-10)
RN  - 138415-26-6 (PRDM1 protein, human)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 2.1.1.- (Positive Regulatory Domain I-Binding Factor 1)
RN  - EC 3.5.4.5 (Cytidine Deaminase)
RN  - MKM3CA6LT1 (interleukin-21)
SB  - IM
MH  - Adult
MH  - B-Lymphocytes/cytology/drug effects/*immunology
MH  - CD40 Antigens/immunology
MH  - Cell Differentiation
MH  - Cytidine Deaminase/*metabolism
MH  - DNA-Binding Proteins/immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*biosynthesis
MH  - In Vitro Techniques
MH  - Interleukin-10/immunology
MH  - Interleukin-4/immunology
MH  - Interleukins/*immunology/pharmacology
MH  - Male
MH  - Middle Aged
MH  - Plasma Cells/cytology/drug effects/*immunology
MH  - Positive Regulatory Domain I-Binding Factor 1
MH  - Receptors, IgG/immunology
MH  - Regulatory Factor X Transcription Factors
MH  - Repressor Proteins/immunology
MH  - Transcription Factors/immunology
MH  - Transcriptional Activation/immunology
MH  - X-Box Binding Protein 1
EDAT- 2008/11/26 09:00
MHDA- 2009/05/13 09:00
CRDT- 2008/11/26 09:00
PHST- 2008/08/13 00:00 [received]
PHST- 2008/10/20 00:00 [revised]
PHST- 2008/10/28 00:00 [accepted]
PHST- 2008/11/26 09:00 [pubmed]
PHST- 2009/05/13 09:00 [medline]
PHST- 2008/11/26 09:00 [entrez]
AID - S0198-8859(08)00525-9 [pii]
AID - 10.1016/j.humimm.2008.10.021 [doi]
PST - ppublish
SO  - Hum Immunol. 2009 Jan;70(1):35-40. doi: 10.1016/j.humimm.2008.10.021. Epub 2008 
      Nov 19.