PMID- 19027490
OWN - NLM
STAT- MEDLINE
DCOM- 20081209
LR  - 20111117
IS  - 1873-4456 (Electronic)
IS  - 0165-4608 (Linking)
VI  - 187
IP  - 2
DP  - 2008 Dec
TI  - Some but not all of HLA-II alleles are associated with cervical cancer in Chinese 
      women.
PG  - 95-100
LID - 10.1016/j.cancergencyto.2008.07.011 [doi]
AB  - Cervical cancer (CC) is closely associated with the human papillomavirus (HPV). 
      Although most patients are able to clear the infection over time, some eventually 
      develop cancer, suggesting the existence of other factors that determine 
      malignant progression. Such factors may include genetic susceptibility. To 
      determine whether human leukocyte antigen (HLA) class II is related to CC among 
      Han race population in the Guangdong region of China, HLA class II typing were 
      carried out by polymerase chain reaction in 126 patients with CC and 88 selected 
      controls. The allele and haplotype frequencies in both the study and control 
      groups were calculated. The occurrence of DPB1 *1301 [odds ratio (OR), 2.66; 95% 
      confidence interval (CI), 1.12-6.29], DPB1 *0202 (OR, 3.65; CI, 1.04-12.80), DQB1 
      *030302(OR, 1.85; CI, 1.04-3.27), and DQB1 *050301(OR, 3.94; CI, 1.48-10.46) 
      alleles were more common in the study group than control. This suggests that 
      these alleles may confer susceptibility to CC in the Guangdong Province. In a 
      similar fashion, the occurrence of DRB1 *13-DQB1 *06 (OR, 0.17; 95% CI, 
      0.04-0.80) haplotype was significantly lower in the study patients compared with 
      the controls and may confer a decreased risk of CC among Han race population in 
      the Guangdong Province of China.
FAU - Liang, Jinxiao
AU  - Liang J
AD  - Second Affiliated Hospital, Sun Yatsen University, 107 Yan Jiang West Road, 
      Guangzhou, 510120, P.R. China.
FAU - Xu, Anlong
AU  - Xu A
FAU - Xie, Yufen
AU  - Xie Y
FAU - Awonuga, Awoniyi O
AU  - Awonuga AO
FAU - Lin, Zhongqiu
AU  - Lin Z
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - China/epidemiology
MH  - Female
MH  - *Gene Frequency
MH  - *Genes, MHC Class II
MH  - HLA-DP Antigens/genetics
MH  - HLA-DP beta-Chains
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - *Haplotypes
MH  - Humans
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Uterine Cervical Neoplasms/blood/epidemiology/*genetics
EDAT- 2008/11/26 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/11/26 09:00
PHST- 2008/04/14 00:00 [received]
PHST- 2008/07/08 00:00 [revised]
PHST- 2008/07/18 00:00 [accepted]
PHST- 2008/11/26 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/11/26 09:00 [entrez]
AID - S0165-4608(08)00467-6 [pii]
AID - 10.1016/j.cancergencyto.2008.07.011 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2008 Dec;187(2):95-100. doi: 
      10.1016/j.cancergencyto.2008.07.011.