PMID- 19027741
OWN - NLM
STAT- MEDLINE
DCOM- 20090505
LR  - 20090112
IS  - 1095-6840 (Electronic)
IS  - 0016-6480 (Linking)
VI  - 160
IP  - 2
DP  - 2009 Jan 15
TI  - Melanocortin peptides affect the motivation to feed in rainbow trout 
      (Oncorhynchus mykiss).
PG  - 134-8
LID - 10.1016/j.ygcen.2008.11.003 [doi]
AB  - In this study, we investigated the effects of one melanocortin receptor (MCR) 
      agonist and two antagonists on food intake in juvenile rainbow trout. Baseline 
      food intake was established prior to 1 microl intracerebroventricular injection 
      (ICV) of the non-specific agonist MTII, the MC4R antagonist HS024 and the MC3/4R 
      antagonist SHU9119 at concentrations of 0.3, 1 or 3 nM. Saline-injected fish and 
      untreated fish served as controls. Changes in food intake were observed 1h after 
      the ICV injections. Our results showed that treatment with MTII significantly 
      decreased food intake at 3 nM compared to control, HS024 significantly increased 
      food intake at 3 nM compared to control and saline-treated fish, and SHU9119 
      significantly increased food intake at 3 nM compared to saline-treated fish. In 
      conclusion, our study provides further evidence, and hence strengthens the 
      hypothesis, that MC4R participates in the control of energy balance in fish in 
      the same manner as in mammals. Our findings that HS024 is more potent than 
      SHU9119 in increasing food intake suggest that the effects of melanocortin on 
      energy balance in rainbow trout are mainly regulated by activation of MC4R. 
      Hence, HS024 seems an excellent tool as a MC4R antagonist in rainbow trout.
FAU - Schjolden, Joachim
AU  - Schjolden J
AD  - Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary 
      Science, P.O. Box 8146 Dep, Ullevalsveien 72, N-0033 Oslo, Norway. 
      joachim.schjolden@veths.no
FAU - Schioth, Helgi B
AU  - Schioth HB
FAU - Larhammar, Dan
AU  - Larhammar D
FAU - Winberg, Svante
AU  - Winberg S
FAU - Larson, Earl T
AU  - Larson ET
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081108
PL  - United States
TA  - Gen Comp Endocrinol
JT  - General and comparative endocrinology
JID - 0370735
RN  - 0 (HS 024)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (Receptor, Melanocortin, Type 3)
RN  - 0 (Receptor, Melanocortin, Type 4)
RN  - 0 (Receptors, Melanocortin)
RN  - 0 
      (acetyl-norleucyl(4)-(aspartyl(5)-histidyl(6)-phenylalanyl(7)-arginyl(8)-tryptophyl(9)-lysyl(10))cyclo-alpha-MSH(4-10)amide)
RN  - 168482-23-3 (SHU 9119)
RN  - 581-05-5 (alpha-MSH)
RN  - 9002-79-3 (Melanocyte-Stimulating Hormones)
SB  - IM
MH  - Animals
MH  - Appetite/drug effects
MH  - Feeding Behavior/*drug effects
MH  - Melanocyte-Stimulating Hormones/administration & dosage/pharmacology
MH  - Oncorhynchus mykiss
MH  - Peptides, Cyclic/administration & dosage/pharmacology
MH  - Receptor, Melanocortin, Type 3/antagonists & inhibitors
MH  - Receptor, Melanocortin, Type 4/antagonists & inhibitors
MH  - Receptors, Melanocortin/agonists/antagonists & inhibitors/*physiology
MH  - alpha-MSH/administration & dosage/analogs & derivatives/pharmacology
EDAT- 2008/11/26 09:00
MHDA- 2009/05/06 09:00
CRDT- 2008/11/26 09:00
PHST- 2008/06/13 00:00 [received]
PHST- 2008/10/16 00:00 [revised]
PHST- 2008/11/01 00:00 [accepted]
PHST- 2008/11/26 09:00 [pubmed]
PHST- 2009/05/06 09:00 [medline]
PHST- 2008/11/26 09:00 [entrez]
AID - S0016-6480(08)00401-2 [pii]
AID - 10.1016/j.ygcen.2008.11.003 [doi]
PST - ppublish
SO  - Gen Comp Endocrinol. 2009 Jan 15;160(2):134-8. doi: 10.1016/j.ygcen.2008.11.003. 
      Epub 2008 Nov 8.