PMID- 19028390
OWN - NLM
STAT- MEDLINE
DCOM- 20090414
LR  - 20211020
IS  - 1097-6833 (Electronic)
IS  - 0022-3476 (Print)
IS  - 0022-3476 (Linking)
VI  - 154
IP  - 4
DP  - 2009 Apr
TI  - Increased prevalence of abnormal glucose tolerance among obese siblings of 
      children with type 2 diabetes.
PG  - 562-566.e1
LID - 10.1016/j.jpeds.2008.09.055 [doi]
AB  - OBJECTIVE: To test the hypothesis that overweight siblings of children with type 
      2 diabetes mellitus (T2DM) have a higher prevalence of abnormal glucose tolerance 
      (AGT) compared with other overweight children. STUDY DESIGN: This was a 
      cross-sectional study of overweight (body mass index [BMI] >or= 95(th) 
      percentile) subjects, age 8 to 17 years, with at least 1 sibling age >or= 12 
      years. The primary outcome was AGT, as assessed by the oral glucose tolerance 
      test (2-hour glucose >or= 140 mg/dL). The secondary outcome was insulin 
      resistance by homeostasis model assessment (HOMA). RESULTS: The sibling (n=20) 
      and control (n=42) groups were similar in terms of age, sex, racial distribution 
      (largely African American), pubertal status, and BMI. The prevalence of AGT in 
      the sibling group was 40.0% (n=8), compared with 14.3% (n=6) in controls (P= 
      .048, Fisher exact test; unadjusted odds ratio=4.0; 95% confidence interval=1.2 
      to 13.5). Univariate analysis did not identify confounders for either outcome. 
      There were no significant differences in HOMA or hemoglobin A1c between the 2 
      groups. CONCLUSIONS: Overweight siblings of children with T2DM had 4 times 
      greater odds of having AGT compared with other overweight children. This group 
      may represent a particularly high-risk population to target for screening and 
      pediatric T2DM prevention.
FAU - Magge, Sheela N
AU  - Magge SN
AD  - Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, 
      Philadelphia, PA 19104, USA. magge@email.chop.edu
FAU - Stettler, Nicolas
AU  - Stettler N
FAU - Jawad, Abbas F
AU  - Jawad AF
FAU - Levitt Katz, Lorraine E
AU  - Levitt Katz LE
LA  - eng
GR  - K12 DK63682/DK/NIDDK NIH HHS/United States
GR  - 5-MO1-RR-000240/RR/NCRR NIH HHS/United States
GR  - M01 RR000240-416771/RR/NCRR NIH HHS/United States
GR  - K12 DK063682/DK/NIDDK NIH HHS/United States
GR  - M01 RR000240/RR/NCRR NIH HHS/United States
GR  - UL1 RR024134/RR/NCRR NIH HHS/United States
GR  - UL1RR024134/RR/NCRR NIH HHS/United States
GR  - K12 DK063682-01/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20081122
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*prevention & control
MH  - *Family Health
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Mass Screening
MH  - Metabolic Syndrome/*epidemiology
MH  - Obesity/*epidemiology
MH  - Philadelphia/epidemiology
MH  - Prevalence
MH  - *Siblings
PMC - PMC2746396
MID - NIHMS106755
COIS- There are no potential conflicts of interest, and the authors have nothing to 
      disclose.
EDAT- 2008/11/26 09:00
MHDA- 2009/04/15 09:00
PMCR- 2009/09/18
CRDT- 2008/11/26 09:00
PHST- 2008/02/13 00:00 [received]
PHST- 2008/09/18 00:00 [revised]
PHST- 2008/09/30 00:00 [accepted]
PHST- 2008/11/26 09:00 [pubmed]
PHST- 2009/04/15 09:00 [medline]
PHST- 2008/11/26 09:00 [entrez]
PHST- 2009/09/18 00:00 [pmc-release]
AID - S0022-3476(08)00865-2 [pii]
AID - 10.1016/j.jpeds.2008.09.055 [doi]
PST - ppublish
SO  - J Pediatr. 2009 Apr;154(4):562-566.e1. doi: 10.1016/j.jpeds.2008.09.055. Epub 
      2008 Nov 22.