PMID- 19028536
OWN - NLM
STAT- MEDLINE
DCOM- 20090512
LR  - 20090109
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 70
IP  - 1
DP  - 2009 Jan
TI  - Adipokines and sublingual immunotherapy: preliminary report.
PG  - 73-8
LID - 10.1016/j.humimm.2008.10.001 [doi]
AB  - Several studies have outlined a possible relationship between an increased body 
      mass index (BMI) and respiratory allergic diseases, such as asthma and rhinitis. 
      Very recently, it has been demonstrated that serum adipokines, such as leptin and 
      adiponectin, may be increased in patients with allergic rhinitis. The aim of the 
      study was to evaluate the serum leptin and adiponectin levels in a cohort of 
      patients with pollen-induced allergic rhinitis, before and after a single 
      preseasonal course of sublingual immunotherapy (SLIT). A total of 41 patients (22 
      male and 19 female, median age 39 years) with AR due to pollen allergy, along 
      with 34 normal subjects, were included in the study. Blood sampling for assessing 
      serum adipokines, immunoglobulin E (IgE) levels, and eosinophils were performed 
      in all subjects before and after the SLIT course. An increasing trend of both 
      adipokines was observed after SLIT, albeit without statistical significance and 
      with gender difference. Leptin was significantly related to some clinical 
      parameters and peripheral eosinophil counts. Conversely, adinopectin showed an 
      inverse significant correlation with peripheral eosinophils counts but only for 
      men. In conclusion, the results of this preliminary study show that a single 
      preseasonal SLIT course does not induce significant modifications in serum 
      adipokines levels but induces only a slight increase.
FAU - Ciprandi, Giorgio
AU  - Ciprandi G
AD  - Department of Internal Medicine, University of Genoa, Italy.
FAU - De Amici, Mara
AU  - De Amici M
FAU - Murdaca, Giuseppe
AU  - Murdaca G
FAU - Filaci, Gilberto
AU  - Filaci G
FAU - Fenoglio, Daniela
AU  - Fenoglio D
FAU - Marseglia, Gian Luigi
AU  - Marseglia GL
LA  - eng
PT  - Journal Article
DEP - 20081124
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Adiponectin)
RN  - 0 (Leptin)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adiponectin/*blood
MH  - Administration, Sublingual
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Blood Cell Count
MH  - Cohort Studies
MH  - Eosinophils/pathology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Immunotherapy/methods
MH  - Leptin/*blood
MH  - Male
MH  - Middle Aged
MH  - Rhinitis, Allergic, Seasonal/*blood/immunology
MH  - Young Adult
EDAT- 2008/11/26 09:00
MHDA- 2009/05/13 09:00
CRDT- 2008/11/26 09:00
PHST- 2008/06/11 00:00 [received]
PHST- 2008/09/11 00:00 [revised]
PHST- 2008/10/01 00:00 [accepted]
PHST- 2008/11/26 09:00 [pubmed]
PHST- 2009/05/13 09:00 [medline]
PHST- 2008/11/26 09:00 [entrez]
AID - S0198-8859(08)00494-1 [pii]
AID - 10.1016/j.humimm.2008.10.001 [doi]
PST - ppublish
SO  - Hum Immunol. 2009 Jan;70(1):73-8. doi: 10.1016/j.humimm.2008.10.001. Epub 2008 
      Nov 24.