PMID- 19030971
OWN - NLM
STAT- MEDLINE
DCOM- 20090114
LR  - 20211020
IS  - 1573-7039 (Electronic)
IS  - 1083-3021 (Print)
IS  - 1083-3021 (Linking)
VI  - 13
IP  - 4
DP  - 2008 Dec
TI  - Insulin receptor substrates (IRSs) and breast tumorigenesis.
PG  - 415-22
LID - 10.1007/s10911-008-9101-9 [doi]
AB  - Insulin receptor substrate (IRS)-1 and IRS-2 are adaptor proteins in the 
      insulin-like growth factor I (IGF-I)/IGF-I receptor (IGF-IR) pathway that mediate 
      cell proliferation, migration, and survival. In addition to their role as 
      scaffolding proteins in the cytoplasm, they are able to translocate into the 
      nucleus and regulate gene transcription. IRS levels are developmentally and 
      hormonally regulated in the normal mammary gland and both are essential for 
      normal mammary gland bud formation and lactation. Both IRS-1 and IRS-2 are 
      transforming oncogenes, and induce transformation and metastasis in vitro and in 
      vivo. In breast cancer IRSs have unique functions, with IRS-1 being mainly 
      involved in cell proliferation and survival, whereas IRS-2 has clear roles in 
      cell migration and metastasis. In this review we will discuss the roles of IRSs 
      in mammary gland development and breast cancer.
FAU - Chan, Bonita Tak-Yee
AU  - Chan BT
AD  - Lester and Sue Smith Breast Center, Department of Medicine and Department of 
      Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
FAU - Lee, Adrian V
AU  - Lee AV
LA  - eng
GR  - R01 CA094118/CA/NCI NIH HHS/United States
GR  - R01 CA094118-05/CA/NCI NIH HHS/United States
GR  - R01CA94118/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20081122
PL  - United States
TA  - J Mammary Gland Biol Neoplasia
JT  - Journal of mammary gland biology and neoplasia
JID - 9601804
RN  - 0 (Insulin Receptor Substrate Proteins)
RN  - 0 (Oncogene Proteins)
SB  - IM
MH  - Animals
MH  - Breast Neoplasms/*metabolism
MH  - Cell Transformation, Neoplastic/*metabolism
MH  - Humans
MH  - Insulin Receptor Substrate Proteins/*metabolism
MH  - Mammary Glands, Animal/growth & development/metabolism
MH  - Mammary Glands, Human/growth & development/metabolism
MH  - Oncogene Proteins/genetics/metabolism
PMC - PMC2819329
MID - NIHMS173185
EDAT- 2008/11/26 09:00
MHDA- 2009/01/15 09:00
PMCR- 2010/02/10
CRDT- 2008/11/26 09:00
PHST- 2008/10/16 00:00 [received]
PHST- 2008/11/03 00:00 [accepted]
PHST- 2008/11/26 09:00 [pubmed]
PHST- 2009/01/15 09:00 [medline]
PHST- 2008/11/26 09:00 [entrez]
PHST- 2010/02/10 00:00 [pmc-release]
AID - 10.1007/s10911-008-9101-9 [doi]
PST - ppublish
SO  - J Mammary Gland Biol Neoplasia. 2008 Dec;13(4):415-22. doi: 
      10.1007/s10911-008-9101-9. Epub 2008 Nov 22.