PMID- 19031023
OWN - NLM
STAT- MEDLINE
DCOM- 20090219
LR  - 20081125
IS  - 0171-2004 (Print)
IS  - 0171-2004 (Linking)
IP  - 188
DP  - 2009
TI  - Lung dendritic cells: targets for therapy in allergic disease.
PG  - 99-114
LID - 10.1007/978-3-540-71029-5_5 [doi]
AB  - Dendritic cells (DCs) are crucial in determining the functional outcome of 
      allergen encounter in the lung. Antigen presentation by myeloid DCs leads to Th2 
      sensitization typical of allergic disease, whereas antigen presentation by 
      plasmacytoid DCs serves to dampen inflammation. It is increasingly clear that DCs 
      have an antigen presenting function beyond sensitisation. DCs therefore 
      constitute a novel target for the development of antiallergic therapy aimed at 
      the origin of the inflammatory cascade. A careful study of DC biology and of the 
      receptors expressed by lung DCs has provided a framework for the discovery of 
      novel antiallergic compounds.
FAU - Lambrecht, Bart N
AU  - Lambrecht BN
AD  - Department of Pulmonary Medicine, Erasmus M.C. Dr. Molerwaterplein 50, 3015 GE, 
      Rotterdam, The Netherlands. b.lambrecht@erasmusmc.nl
FAU - Hammad, Hamida
AU  - Hammad H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Germany
TA  - Handb Exp Pharmacol
JT  - Handbook of experimental pharmacology
JID - 7902231
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Cytokines)
RN  - 0 (Receptors, Immunologic)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/*therapeutic use
MH  - Antigen Presentation
MH  - Cytokines/metabolism
MH  - Dendritic Cells/drug effects/*immunology
MH  - Humans
MH  - Immune Tolerance
MH  - Immunity, Innate
MH  - Lung/drug effects/*immunology
MH  - Lymphocyte Activation
MH  - Receptors, Immunologic/metabolism
MH  - Respiratory Hypersensitivity/drug therapy/*immunology
MH  - T-Lymphocytes, Regulatory/immunology
RF  - 83
EDAT- 2008/11/26 09:00
MHDA- 2009/02/20 09:00
CRDT- 2008/11/26 09:00
PHST- 2008/11/26 09:00 [pubmed]
PHST- 2009/02/20 09:00 [medline]
PHST- 2008/11/26 09:00 [entrez]
AID - 10.1007/978-3-540-71029-5_5 [doi]
PST - ppublish
SO  - Handb Exp Pharmacol. 2009;(188):99-114. doi: 10.1007/978-3-540-71029-5_5.