PMID- 19031029
OWN - NLM
STAT- MEDLINE
DCOM- 20090219
LR  - 20131121
IS  - 0171-2004 (Print)
IS  - 0171-2004 (Linking)
IP  - 188
DP  - 2009
TI  - Handbook of experimental pharmacology "dendritic cells": the use of dexamethasone 
      in the induction of tolerogenic DCs.
PG  - 233-49
LID - 10.1007/978-3-540-71029-5_11 [doi]
AB  - Dendritic cells (DCs) have a central role in immune regulation, ranging from 
      tolerance induction to the induction of specific immune responses. DCs serve as 
      an essential link between innate and adaptive immunity. This broad range of 
      powerful immune stimulatory as well as regulatory functions has made DCs as 
      targets for vaccine development strategies. One approach to promote the 
      tolerogenicity of DCs is to suppress their maturation by pharmacological agents, 
      including glucocorticoids (GCs). In the present chapter we will review GCs used 
      in vitro with cultured DCs, applied in vivo, or used to generate tolerogenic DCs 
      for cellular therapy.
FAU - van Kooten, Cees
AU  - van Kooten C
AD  - Department of Nephrology, Leiden University Medical Center, C3P, Albinusdreef 2, 
      P.O. Box 9600, Leiden, NL-2300RC, The Netherlands. C.van_Kooten@lumc.nl
FAU - Stax, Annelein S
AU  - Stax AS
FAU - Woltman, Andrea M
AU  - Woltman AM
FAU - Gelderman, Kyra A
AU  - Gelderman KA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Handb Exp Pharmacol
JT  - Handbook of experimental pharmacology
JID - 7902231
RN  - 0 (Cytokines)
RN  - 0 (Immunosuppressive Agents)
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/drug effects
MH  - Apoptosis/drug effects
MH  - Autoimmunity/drug effects
MH  - Cell Shape/drug effects
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*drug effects/immunology/transplantation
MH  - Dexamethasone/*pharmacology
MH  - Graft Rejection/immunology/*prevention & control
MH  - Humans
MH  - Immune Tolerance/*drug effects/genetics
MH  - Immunosuppressive Agents/*pharmacology
MH  - Immunotherapy, Adoptive
MH  - Inflammation/immunology/*prevention & control
MH  - Phenotype
MH  - Signal Transduction/drug effects
MH  - T-Lymphocytes/drug effects/immunology
RF  - 90
EDAT- 2008/11/26 09:00
MHDA- 2009/02/20 09:00
CRDT- 2008/11/26 09:00
PHST- 2008/11/26 09:00 [pubmed]
PHST- 2009/02/20 09:00 [medline]
PHST- 2008/11/26 09:00 [entrez]
AID - 10.1007/978-3-540-71029-5_11 [doi]
PST - ppublish
SO  - Handb Exp Pharmacol. 2009;(188):233-49. doi: 10.1007/978-3-540-71029-5_11.