PMID- 19031376
OWN - NLM
STAT- MEDLINE
DCOM- 20090224
LR  - 20211020
IS  - 1556-9039 (Print)
IS  - 1937-6995 (Electronic)
IS  - 1556-9039 (Linking)
VI  - 4
IP  - 4
DP  - 2008 Dec
TI  - Accidental dextromethorphan ingestions in children less than 5 years old.
PG  - 251-3
AB  - INTRODUCTION: The purpose of this study is to evaluate the clinical presentation 
      of accidental dextromethorphan (DXM) ingestions in children <5 years old. Two 
      consecutive years of poison center patient encounters were reviewed. Data 
      including age, outcomes, amount of DXM ingested, co-ingestions, vital signs, 
      clinical manifestations, hospital admissions, and mortality were abstracted. Data 
      were analyzed using descriptive statistics. DISCUSSION: A total of 304 cases were 
      identified with a mean age of 28.2 months (72% were > or =23 months). All cases 
      co-ingested other products of over-the-counter cough and cold medications (i.e., 
      acetaminophen, pseudoephedrine, guaifenesin, ibuprofen, various H1 receptor 
      antagonists, and very infrequently ethanol). The mean DXM dose ingested was 35.0 
      mg (2.64 mg/kg). Of the patients, 62 (20.4%) experienced lethargy as the sole 
      neurological sign and no patient had any cardiovascular abnormalities. Only 1 
      (13-monthold) patient, who ingested 3.2 mg/kg and presented with lethargy, was 
      hospitalized and subsequently discharged 14 hours later. No deaths were recorded. 
      CONCLUSION: As demonstrated in our patient population, accidental ingestions of 
      DXM in the pediatric patient did well with supportive care alone and rarely 
      required inpatient treatment.
FAU - LoVecchio, Frank
AU  - LoVecchio F
AD  - Department of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, 
      AZ 85006, USA. Frank.LoVecchio@bannerhealth.com
FAU - Pizon, Anthony
AU  - Pizon A
FAU - Matesick, Leslie
AU  - Matesick L
FAU - O'Patry, Sean
AU  - O'Patry S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Toxicol
JT  - Journal of medical toxicology : official journal of the American College of 
      Medical Toxicology
JID - 101284598
RN  - 0 (Antitussive Agents)
RN  - 7355X3ROTS (Dextromethorphan)
SB  - IM
MH  - *Accidents, Home
MH  - Antitussive Agents/*poisoning
MH  - Child, Preschool
MH  - Dextromethorphan/*poisoning
MH  - Eating
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant
MH  - Poison Control Centers/statistics & numerical data
MH  - Reproducibility of Results
MH  - Treatment Outcome
PMC - PMC3550111
EDAT- 2008/11/26 09:00
MHDA- 2009/02/25 09:00
PMCR- 2009/12/01
CRDT- 2008/11/26 09:00
PHST- 2008/11/26 09:00 [pubmed]
PHST- 2009/02/25 09:00 [medline]
PHST- 2008/11/26 09:00 [entrez]
PHST- 2009/12/01 00:00 [pmc-release]
AID - BF03161208 [pii]
AID - 10.1007/BF03161208 [doi]
PST - ppublish
SO  - J Med Toxicol. 2008 Dec;4(4):251-3. doi: 10.1007/BF03161208.