PMID- 19032360
OWN - NLM
STAT- MEDLINE
DCOM- 20090330
LR  - 20090203
IS  - 1365-2222 (Electronic)
IS  - 0954-7894 (Linking)
VI  - 39
IP  - 2
DP  - 2009 Feb
TI  - Early-life rotavirus and norovirus infections in relation to development of 
      atopic manifestation in infants.
PG  - 254-60
LID - 10.1111/j.1365-2222.2008.03128.x [doi]
AB  - BACKGROUND: The increase in incidence of atopic diseases (ADs) in the developed 
      world over the past decades has been associated with reduced exposure of 
      childhood infections. OBJECTIVE: To investigate the relation between early 
      intestinal viral infections in relation to the development of atopic symptoms 
      (eczema, wheeze and atopic sensitization) in the first and second year(s) of 
      life. METHODS: In the KOALA Birth Cohort Study, we assessed IgG seropositivity 
      for rota- and norovirus (GGI.1 and GGII.4) at 1 year of age. This was related to 
      allergic sensitization [specific immunoglobulin E (IgE)] at 1 and 2 years, and 
      parent reported eczema and wheeze in the first 2 years, using logistic regression 
      analysis adjusted for confounders. RESULTS: Rotavirus seropositivity (39%) was 
      associated with an unexpected higher risk of recurrent wheeze in the first and 
      second year of life [adjusted odds ratio (OR) 3.1 and 95% confidence intervals 
      (CI) 1.1-9.1] and persistent and new recurrent wheeze (adjusted OR 2.7 and 95% CI 
      1.1-6.2). No further associations were found between intestinal viral 
      seropositivity and atopic manifestations. CONCLUSION: Our data did not show a 
      clear protection by enteric viral infections in young children on development of 
      IgE response to allergens, but rotavirus infection in the first year was a risk 
      factor for wheeze. However, this needs to be followed up to older ages in order 
      to establish the true importance of intestinal viral infections and especially 
      cumulative effects in AD aetiology. Exposure to rotavirus may offer a new and 
      interesting focus on infant wheeze and later asthma development.
FAU - Reimerink, J
AU  - Reimerink J
AD  - Laboratory for Infectious Diseases and Screening, National Institute of Public 
      Health and the Environment (RIVM), Bilthoven, Maastricht, Amsterdam, The 
      Netherlands. johan.reimerink@rivm.nl
FAU - Stelma, F
AU  - Stelma F
FAU - Rockx, B
AU  - Rockx B
FAU - Brouwer, D
AU  - Brouwer D
FAU - Stobberingh, E
AU  - Stobberingh E
FAU - van Ree, R
AU  - van Ree R
FAU - Dompeling, E
AU  - Dompeling E
FAU - Mommers, M
AU  - Mommers M
FAU - Thijs, C
AU  - Thijs C
FAU - Koopmans, M
AU  - Koopmans M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081117
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy 
      and Clinical Immunology
JID - 8906443
RN  - 0 (Allergens)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigens, Viral)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - Clin Exp Allergy. 2009 Feb;39(2):179-80. PMID: 19187329
MH  - Allergens/immunology
MH  - Antibodies, Viral/blood
MH  - Antigens, Viral/immunology
MH  - Caliciviridae Infections/*complications/*epidemiology/immunology
MH  - Child, Preschool
MH  - Dermatitis, Atopic/epidemiology/etiology
MH  - Female
MH  - Humans
MH  - Hypersensitivity/epidemiology/*etiology/immunology/*virology
MH  - Immunoglobulin E/blood/immunology
MH  - Infant
MH  - Male
MH  - Netherlands/epidemiology
MH  - *Norovirus/immunology
MH  - Odds Ratio
MH  - Respiratory Sounds/etiology
MH  - Risk Factors
MH  - Rotavirus Infections/*complications/*epidemiology/immunology
MH  - Seroepidemiologic Studies
EDAT- 2008/11/27 09:00
MHDA- 2009/03/31 09:00
CRDT- 2008/11/27 09:00
PHST- 2008/11/27 09:00 [pubmed]
PHST- 2009/03/31 09:00 [medline]
PHST- 2008/11/27 09:00 [entrez]
AID - CEA3128 [pii]
AID - 10.1111/j.1365-2222.2008.03128.x [doi]
PST - ppublish
SO  - Clin Exp Allergy. 2009 Feb;39(2):254-60. doi: 10.1111/j.1365-2222.2008.03128.x. 
      Epub 2008 Nov 17.