PMID- 19032678
OWN - NLM
STAT- MEDLINE
DCOM- 20081223
LR  - 20211203
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 86 Thesis 4
DP  - 2008 Nov
TI  - Receptors for the liver synthesized growth factors IGF-1 and HGF/SF in uveal 
      melanoma: intercorrelation and prognostic implications.
PG  - 20-5
LID - 10.1111/j.1755-3768.2008.01182.x [doi]
AB  - PURPOSE: Uveal melanoma disseminates preferentially to the liver. The mechanism 
      for this homing is largely unknown, but growth factors synthesized in the liver 
      may be involved. The present study was undertaken to investigate the possible 
      relationship between cell surface receptors for two such growth factors: the 
      c-Met proto-oncogene, which constitutes the receptor for hepatocyte growth 
      factor/scatter factor (HGF/SF), and the insulin-like growth factor 1 receptor 
      (IGF-1R). Their role as a prognostic factor was also clarified. METHODS: 
      Paraffin-embedded tumor specimens from 132 patients with primary uveal melanoma 
      were analyzed by using well-established specific antibodies against c-Met and 
      IGF-1R. The intercorrelation of receptor expression and association with 
      melanoma-related survival of patients were determined by univariate and 
      multivariate analyses. RESULTS: Whereas the expression of both IGF-1R and c-Met 
      was significantly associated with melanoma-specific mortality by univariate 
      analysis (p = 0.004 and p = 0.007, respectively) only IGF-1R showed independent 
      prognostic value by multivariate analysis, p = 0.004. The prognostic value of 
      IGF-1R was stronger than such currently used prognostic parameters as tumor cell 
      type and tumor diameter (p = 0.021 and p = 0.026, respectively). The expression 
      patterns of the two growth factors receptors were weakly intercorrelated. 
      CONCLUSIONS: In conclusion, the data suggest that the receptors for IGF-1 and 
      HGF/SF may play a role in the spread of uveal melanoma and its affinity to the 
      liver. The strong correlation between IGF-1R expression and melanoma-specific 
      mortality points to the use of IGF-1R as a prognostic tool [Economou MA, 
      All-Ericsson C, Bykov V, Girnita L, Bartolazzi A, Larsson O & Seregard S (2005): 
      Receptors for the liver synthesized growth factors IGF-1 and HGF/SF in uveal 
      melanoma: intercorrelation and prognostic implications.
FAU - Economou, Mario A
AU  - Economou MA
AD  - Cellular and Molecular Tumor Pathology, Department of Oncology and Pathology, 
      Karolinska Hospital, Stockholm, Sweden.
FAU - All-Ericsson, Charlotta
AU  - All-Ericsson C
FAU - Bykov, Vladimir
AU  - Bykov V
FAU - Girnita, Leonard
AU  - Girnita L
FAU - Bartolazzi, Armando
AU  - Bartolazzi A
FAU - Larsson, Olle
AU  - Larsson O
FAU - Seregard, Stefan
AU  - Seregard S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
RN  - 0 (MAS1 protein, human)
RN  - 0 (Proto-Oncogene Mas)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
RN  - EC 2.7.10.1 (Receptor, IGF Type 1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Immunologic Techniques
MH  - Kaplan-Meier Estimate
MH  - Liver/*metabolism
MH  - Liver Neoplasms/secondary
MH  - Male
MH  - Melanoma/*metabolism/mortality/secondary
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Proto-Oncogene Mas
MH  - Proto-Oncogene Proteins c-met/biosynthesis/*metabolism
MH  - Receptor, IGF Type 1/biosynthesis/*metabolism
MH  - Staining and Labeling
MH  - Uveal Neoplasms/*metabolism/mortality
EDAT- 2008/11/27 09:00
MHDA- 2008/12/24 09:00
CRDT- 2008/11/27 09:00
PHST- 2008/11/27 09:00 [pubmed]
PHST- 2008/12/24 09:00 [medline]
PHST- 2008/11/27 09:00 [entrez]
AID - AOS1182 [pii]
AID - 10.1111/j.1755-3768.2008.01182.x [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2008 Nov;86 Thesis 4:20-5. doi: 
      10.1111/j.1755-3768.2008.01182.x.