PMID- 19032708
OWN - NLM
STAT- MEDLINE
DCOM- 20090408
LR  - 20081126
IS  - 1399-5618 (Electronic)
IS  - 1398-5647 (Linking)
VI  - 10
IP  - 7
DP  - 2008 Nov
TI  - Increased rates of white matter hyperintensities in late-onset bipolar disorder.
PG  - 765-75
LID - 10.1111/j.1399-5618.2008.00621.x [doi]
AB  - OBJECTIVES: Magnetic resonance imaging (MRI) studies have reported an increased 
      frequency of white matter hyperintensities (WMH) in association with late-onset 
      (LO) depression, and this has supported the notion that vascular-related 
      mechanisms may be implicated in the pathophysiology of LO mood disorders. Recent 
      clinical studies have also suggested a link between LO bipolar disorder (LO-BD) 
      and cerebrovascular risk factors, but this has been little investigated with 
      neuroimaging techniques. In order to ascertain whether there could be a specific 
      association between WMH and LO-BD, we directly compared WMH rates between LO-BD 
      subjects (illness onset >or= 60 years), early-onset BD subjects (EO-BD, illness 
      onset <60 years), and elderly healthy volunteers. METHODS: T2-weighted MRI data 
      were acquired in LO-BD subjects (n = 10, age = 73.60 +/- 4.09), EO-BD patients (n 
      = 49, age = 67.78 +/- 4.44), and healthy subjects (n = 24, age = 69.00 +/- 7.22). 
      WMH rates were assessed using the Scheltens scale. RESULTS: There was a greater 
      prevalence of WMH in LO-BD patients relative to the two other groups in the deep 
      parietal region (p = 0.018) and basal ganglia (p < 0.045). When between-group 
      comparisons of mean WMH scores were conducted taking account of age differences 
      (ANCOVA), there were more severe scores in LO-BD patients relative to the two 
      other groups in deep frontal and parietal regions, as well as in the putamen (p < 
      0.05). CONCLUSIONS: Our results provide empirical support to the proposed link 
      between vascular risk factors and LO-BD. If extended in future studies with 
      larger samples, these findings may help to clarify the pathophysiological 
      distinctions between bipolar disorder emerging at early and late stages of life.
FAU - Tamashiro, Jaqueline Hatsuko
AU  - Tamashiro JH
AD  - Department of Psychiatry, University of Sao Paulo Medical School, Sao Paulo, 
      Brazil. jhatsu@gmail.com
FAU - Zung, Stevin
AU  - Zung S
FAU - Zanetti, Marcus Vinicius
AU  - Zanetti MV
FAU - de Castro, Claudio Campi
AU  - de Castro CC
FAU - Vallada, Homero
AU  - Vallada H
FAU - Busatto, Geraldo F
AU  - Busatto GF
FAU - de Toledo Ferraz Alves, Tania Correa
AU  - de Toledo Ferraz Alves TC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Bipolar Disord
JT  - Bipolar disorders
JID - 100883596
SB  - IM
MH  - Age of Onset
MH  - Aged
MH  - Analysis of Variance
MH  - Bipolar Disorder/classification/*pathology
MH  - Brain/*pathology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Nerve Fibers, Myelinated/*pathology
EDAT- 2008/11/27 09:00
MHDA- 2009/04/09 09:00
CRDT- 2008/11/27 09:00
PHST- 2008/11/27 09:00 [pubmed]
PHST- 2009/04/09 09:00 [medline]
PHST- 2008/11/27 09:00 [entrez]
AID - BDI621 [pii]
AID - 10.1111/j.1399-5618.2008.00621.x [doi]
PST - ppublish
SO  - Bipolar Disord. 2008 Nov;10(7):765-75. doi: 10.1111/j.1399-5618.2008.00621.x.