PMID- 19033682
OWN - NLM
STAT- MEDLINE
DCOM- 20090417
LR  - 20131121
IS  - 1421-9697 (Electronic)
IS  - 0250-6807 (Linking)
VI  - 53
IP  - 3-4
DP  - 2008
TI  - Effect of vanadium on insulin sensitivity in patients with impaired glucose 
      tolerance.
PG  - 195-8
LID - 10.1159/000175844 [doi]
AB  - BACKGROUND/AIM: Impaired glucose tolerance (IGT) is considered a risk factor for 
      developing type 2 diabetes mellitus (T2DM) and is associated with insulin 
      resistance. Vanadium seems to block protein tyrosine phosphatase with the 
      consequent increment in insulin sensitivity (INS) in T2DM patients, but this 
      effect has not been studied in IGT patients. The aim of this study was to 
      evaluate the effect of vanadium on INS in IGT patients. METHODS: A randomized, 
      double-blind, placebo-controlled clinical trial was carried out in 14 
      overweight/obese patients with IGT. Intervention consisted of vanadyl sulfate 
      (VS, 50 mg p.o. twice daily) or placebo for 4 weeks. Before and after the 
      intervention, a metabolic profile was performed and INS was assessed using the 
      euglycemic-hyperinsulinemic clamp technique. Mann-Whitney U and Wilcoxon rank 
      tests were used for statistical analyses. RESULTS: There were no significant 
      differences in basal characteristics between groups. VS did not affect INS 
      [2.7+/-0.8 vs. 2.9+/-0.9 mg/(kg/min), p=0.735] but increased triglyceride levels 
      (1.35+/-0.61 vs. 1.70+/-0.46 mmol/l, p=0.018). CONCLUSIONS: VS administration in 
      IGT patients increased triglyceride concentrations without changes in INS.
CI  - Copyright 2008 S. Karger AG, Basel.
FAU - Jacques-Camarena, Omar
AU  - Jacques-Camarena O
AD  - Medical Research Unit in Clinical Epidemiology, Medical Unit of High Specialty, 
      West National Medical Center, Mexican Institute of Social Security, Guadalajara, 
      Mexico.
FAU - Gonzalez-Ortiz, Manuel
AU  - Gonzalez-Ortiz M
FAU - Martinez-Abundis, Esperanza
AU  - Martinez-Abundis E
FAU - Lopez-Madrueno, J F Pariz
AU  - Lopez-Madrueno JF
FAU - Medina-Santillan, Roberto
AU  - Medina-Santillan R
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20081122
PL  - Switzerland
TA  - Ann Nutr Metab
JT  - Annals of nutrition & metabolism
JID - 8105511
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Trace Elements)
RN  - 0 (Triglycerides)
RN  - 00J9J9XKDE (Vanadium)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - Double-Blind Method
MH  - Female
MH  - Glucose Clamp Technique
MH  - Glucose Intolerance/blood/*drug therapy
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/*blood
MH  - Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - Statistics, Nonparametric
MH  - Trace Elements/pharmacology
MH  - Treatment Outcome
MH  - Triglycerides/blood
MH  - Vanadium/*pharmacology
EDAT- 2008/11/27 09:00
MHDA- 2009/04/18 09:00
CRDT- 2008/11/27 09:00
PHST- 2008/03/28 00:00 [received]
PHST- 2008/09/11 00:00 [accepted]
PHST- 2008/11/27 09:00 [pubmed]
PHST- 2009/04/18 09:00 [medline]
PHST- 2008/11/27 09:00 [entrez]
AID - 000175844 [pii]
AID - 10.1159/000175844 [doi]
PST - ppublish
SO  - Ann Nutr Metab. 2008;53(3-4):195-8. doi: 10.1159/000175844. Epub 2008 Nov 22.