PMID- 19034257
OWN - NLM
STAT- MEDLINE
DCOM- 20090303
LR  - 20220410
IS  - 0026-4806 (Print)
IS  - 1827-1669 (Electronic)
IS  - 0026-4806 (Linking)
VI  - 99
IP  - 6
DP  - 2008 Dec
TI  - Liver involvement in celiac disease.
PG  - 595-604
AB  - Celiac disease is a chronic immune-mediated disorder that may affect several 
      organs. Liver abnormalities are common extraintestinal manifestations of celiac 
      disease. Isolated hypertransaminasemia, with mild or nonspecific histologic 
      changes in the liver biopsy, also known as ''celiac hepatitis'', is the most 
      frequent presentation of liver injury in celiac disease. Both, histologic changes 
      and liver enzymes reverse to normal after treatment with a gluten-free diet in 
      most patients. Celiac disease may also be associated with severe forms of liver 
      disease and/or coexist with other chronic liver disorders (i.e., autoimmune liver 
      diseases). The mechanisms underlying liver injury in celiac disease are poorly 
      understood. Predisposition to autoimmunity by shared genetic factors (i.e., human 
      leukocyte antigen [HLA] genes) as well as the systemic effects of abnormal 
      intestinal permeability, cytokines, autoantibodies, and/or other yet undefined 
      biologic mediators induced by gluten exposure in susceptible persons may play a 
      pathogenic role. The aims of this article are: 1) to review the spectrum of liver 
      injury related to celiac disease and 2) to understand the clinical implications 
      of celiac disease in patients with chronic liver disorders.
FAU - Rubio-Tapia, A
AU  - Rubio-Tapia A
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic 
      College of Medicine, Rochester, MN 55905, USA.
FAU - Murray, J A
AU  - Murray JA
LA  - eng
GR  - T32 AI-07047/AI/NIAID NIH HHS/United States
GR  - R01 DK071003/DK/NIDDK NIH HHS/United States
GR  - R01 DK057892/DK/NIDDK NIH HHS/United States
GR  - DK-070031/DK/NIDDK NIH HHS/United States
GR  - DK-57892/DK/NIDDK NIH HHS/United States
GR  - T32 AI007047/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - Italy
TA  - Minerva Med
JT  - Minerva medica
JID - 0400732
SB  - IM
MH  - Biopsy
MH  - Celiac Disease/*complications/diagnosis/pathology
MH  - Humans
MH  - Liver/pathology
MH  - Liver Diseases/diagnosis/*etiology/pathology
PMC - PMC3941070
MID - NIHMS554086
EDAT- 2008/11/27 09:00
MHDA- 2009/03/04 09:00
PMCR- 2014/03/04
CRDT- 2008/11/27 09:00
PHST- 2008/11/27 09:00 [pubmed]
PHST- 2009/03/04 09:00 [medline]
PHST- 2008/11/27 09:00 [entrez]
PHST- 2014/03/04 00:00 [pmc-release]
PST - ppublish
SO  - Minerva Med. 2008 Dec;99(6):595-604.