PMID- 19034830
OWN - NLM
STAT- MEDLINE
DCOM- 20090520
LR  - 20211020
IS  - 0032-0943 (Print)
IS  - 1439-0221 (Electronic)
IS  - 0032-0943 (Linking)
VI  - 75
IP  - 4
DP  - 2009 Mar
TI  - Inhibition of human dendritic cell activation by hydroethanolic but not 
      lipophilic extracts of turmeric (Curcuma longa).
PG  - 312-5
LID - 10.1055/s-0028-1088367 [doi]
AB  - Turmeric has been extensively utilized in Indian and Chinese medicine for its 
      immune-modulatory properties. Dendritic cells (DCs) are antigen-presenting cells 
      specialized to initiate and regulate immunity. The ability of DCs to initiate 
      immunity is linked to their activation status. The effects of turmeric on human 
      DCs have not been studied. Here we show that hydroethanolic (HEE) but not 
      lipophilic "supercritical" extraction (SCE) of turmeric inhibits the activation 
      of human DCs in response to inflammatory cytokines. Treatment of DCs with HEE 
      also inhibits the ability of DCs to stimulate the mixed lymphocyte reaction 
      (MLR). Importantly, the lipophilic fraction does not synergize with the 
      hydroethanolic fraction for the ability of inhibiting DC maturation. Rather, 
      culturing of DCs with the combination of HEE and SCE leads to partial abrogation 
      of the effects of HEE on the MLR initiated by DCs. These data provide a mechanism 
      for the anti-inflammatory properties of turmeric. However, they suggest that 
      these extracts are not synergistic and may contain components with mutually 
      antagonistic effects on human DCs. Harnessing the immune effects of turmeric may 
      benefit from specifically targeting the active fractions.
FAU - Krasovsky, Joseph
AU  - Krasovsky J
AD  - Laboratory of Tumor Immunology and Immunotherapy, The Rockefeller University, New 
      York, New York, USA.
FAU - Chang, David H
AU  - Chang DH
FAU - Deng, Gary
AU  - Deng G
FAU - Yeung, Simon
AU  - Yeung S
FAU - Lee, Mavis
AU  - Lee M
FAU - Leung, Ping Chung
AU  - Leung PC
FAU - Cunningham-Rundles, Susanna
AU  - Cunningham-Rundles S
FAU - Cassileth, Barrie
AU  - Cassileth B
FAU - Dhodapkar, Madhav V
AU  - Dhodapkar MV
LA  - eng
GR  - P30 CA008748/CA/NCI NIH HHS/United States
GR  - P50 AT002779/AT/NCCIH NIH HHS/United States
GR  - 1 P50 AT002779-01/AT/NCCIH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20081125
PL  - Germany
TA  - Planta Med
JT  - Planta medica
JID - 0066751
RN  - 0 (Cytokines)
RN  - 0 (Immunologic Factors)
RN  - 0 (Lipids)
RN  - 0 (Plant Extracts)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Cells, Cultured
MH  - Curcuma/*chemistry
MH  - Cytokines/*pharmacology
MH  - Dendritic Cells/*drug effects/physiology
MH  - Ethanol/chemistry
MH  - Humans
MH  - Immunologic Factors/chemistry/pharmacology
MH  - Lipids/chemistry
MH  - Plant Extracts/*chemistry/*pharmacology
PMC - PMC4566996
MID - NIHMS680724
EDAT- 2008/11/27 09:00
MHDA- 2009/05/21 09:00
PMCR- 2015/09/11
CRDT- 2008/11/27 09:00
PHST- 2008/11/27 09:00 [pubmed]
PHST- 2009/05/21 09:00 [medline]
PHST- 2008/11/27 09:00 [entrez]
PHST- 2015/09/11 00:00 [pmc-release]
AID - 10.1055/s-0028-1088367 [doi]
PST - ppublish
SO  - Planta Med. 2009 Mar;75(4):312-5. doi: 10.1055/s-0028-1088367. Epub 2008 Nov 25.