PMID- 19035461
OWN - NLM
STAT- MEDLINE
DCOM- 20090223
LR  - 20160303
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 124
IP  - 6
DP  - 2009 Mar 15
TI  - Curcumin in combination with visible light inhibits tumor growth in a xenograft 
      tumor model.
PG  - 1422-8
LID - 10.1002/ijc.23997 [doi]
AB  - It is known that curcumin, a dietary pigment from the plant Curcuma longa, 
      inhibits cell proliferation and induces apoptosis in different cell lines; 
      however, the therapeutic benefit is hampered by very low absorption after 
      transdermal or oral application. Recent studies from our laboratory have 
      demonstrated that curcumin at low concentrations (0.2-1 microg/ml) offered the 
      described effects only when applied with UVA or visible light. Nevertheless, the 
      in vivo efficacy of this combination is lacking. In the present study, we used a 
      xenograft tumor model with human epithelial carcinoma A431 cells to test the 
      effect of curcumin and visible light on tumor growth. It was found that tumor 
      growth was significantly inhibited in mice that were i.p. injected with curcumin 
      and consecutively irradiated with visible light. Furthermore, 
      immunohistochemistry showed a reduction of Ki 67 expression, indicating a 
      decrease of cycling cells and induction of apoptotic bodies. The effect on 
      apoptosis was further confirmed by Western blot analysis showing enhanced 
      activation of caspases-9. Vice versa inhibition of extracellular regulated 
      kinases (ERK) 1/2 and epidermal growth factor receptor (EGF-R) was observed which 
      may aid inhibition of proliferation and induction of apoptosis. In summary, the 
      present findings suggest a combination of curcumin and light as a new therapeutic 
      concept to increase the efficacy of curcumin in the treatment of cancer.
FAU - Dujic, Jadranka
AU  - Dujic J
AD  - Department of Dermatology and Venerology, JW Goethe-University, Medical School, 
      Frankfurt, Main, Germany.
FAU - Kippenberger, Stefan
AU  - Kippenberger S
FAU - Ramirez-Bosca, Ana
AU  - Ramirez-Bosca A
FAU - Diaz-Alperi, Joaquin
AU  - Diaz-Alperi J
FAU - Bereiter-Hahn, Jurgen
AU  - Bereiter-Hahn J
FAU - Kaufmann, Roland
AU  - Kaufmann R
FAU - Bernd, August
AU  - Bernd A
FAU - Hofmann, Matthias
AU  - Hofmann M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Anti-Inflammatory Agents)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - Apoptosis/drug effects
MH  - Carcinoma, Squamous Cell/pathology
MH  - Cell Division/drug effects
MH  - Cell Survival/drug effects
MH  - Curcuma
MH  - Curcumin/*therapeutic use
MH  - Humans
MH  - Mice
MH  - Mice, Nude
MH  - *Photic Stimulation
MH  - Transplantation, Heterologous
MH  - Ultraviolet Rays
EDAT- 2008/11/28 09:00
MHDA- 2009/02/24 09:00
CRDT- 2008/11/28 09:00
PHST- 2008/11/28 09:00 [pubmed]
PHST- 2009/02/24 09:00 [medline]
PHST- 2008/11/28 09:00 [entrez]
AID - 10.1002/ijc.23997 [doi]
PST - ppublish
SO  - Int J Cancer. 2009 Mar 15;124(6):1422-8. doi: 10.1002/ijc.23997.