PMID- 19035978
OWN - NLM
STAT- MEDLINE
DCOM- 20090706
LR  - 20090203
IS  - 1365-2036 (Electronic)
IS  - 0269-2813 (Linking)
VI  - 29
IP  - 5
DP  - 2009 Mar 1
TI  - Socio-demographic factors influence chronic proton pump inhibitor use by a large 
      population in the Netherlands.
PG  - 571-9
LID - 10.1111/j.1365-2036.2008.03900.x [doi]
AB  - BACKGROUND: Chronic proton pump inhibitor (PPI) use is common in the Western 
      world. Socio-economic status and socio-demographic factors have been shown to 
      influence decisions related to prescribing of various drugs, but the influence of 
      these factors on chronic PPI use is uncertain. AIM: To study the influence of SES 
      and socio-demographic factors on chronic PPI use. METHODS: Data were collected 
      from a database of a Dutch health insurance company. Subjects having had at least 
      one prescription for a PPI were identified and followed up for 6 months. Patients 
      were then subdivided into chronic PPI users. Socio-demographic status was based 
      on neighbourhood level of residence. Logistic regression was performed to 
      determine socio-demographic factors associated with PPI use. RESULTS: A total of 
      2 001 787 insured individuals were included, 85 253 subjects were chronic users. 
      Both low income (OR 1.55; CI 1.52-1.58) and low educational level (OR 1.33; CI 
      1.31-1.36) were associated with chronic PPI use. Other independent predictive 
      variables included use of 10 or more concomitant medications (OR 5.33; CI 
      4.96-5.72) and the use of prokinetic drugs (OR 10.01; CI 9.22-10.88). 
      CONCLUSIONS: Patients of a lower socio-demographic status are more likely to use 
      PPIs on a chronic basis. The observed gradient in PPIs use may reflect 
      differences in health, healthcare use or healthcare supply.
FAU - van Boxel, O S
AU  - van Boxel OS
AD  - Department of Gastroenterology and Hepatology, University Medical Center Utrecht, 
      Utrecht, The Netherlands.
FAU - Hagenaars, M P
AU  - Hagenaars MP
FAU - Smout, A J P M
AU  - Smout AJ
FAU - Siersema, P D
AU  - Siersema PD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081125
PL  - England
TA  - Aliment Pharmacol Ther
JT  - Alimentary pharmacology & therapeutics
JID - 8707234
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
MH  - Cohort Studies
MH  - Drug Prescriptions/statistics & numerical data
MH  - Drug Utilization/statistics & numerical data
MH  - Female
MH  - Gastrointestinal Diseases/*drug therapy
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Netherlands
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Retrospective Studies
MH  - Socioeconomic Factors
MH  - Time Factors
MH  - Young Adult
EDAT- 2008/11/28 09:00
MHDA- 2009/07/07 09:00
CRDT- 2008/11/28 09:00
PHST- 2008/11/28 09:00 [pubmed]
PHST- 2009/07/07 09:00 [medline]
PHST- 2008/11/28 09:00 [entrez]
AID - APT3900 [pii]
AID - 10.1111/j.1365-2036.2008.03900.x [doi]
PST - ppublish
SO  - Aliment Pharmacol Ther. 2009 Mar 1;29(5):571-9. doi: 
      10.1111/j.1365-2036.2008.03900.x. Epub 2008 Nov 25.