PMID- 19037595
OWN - NLM
STAT- MEDLINE
DCOM- 20090507
LR  - 20211020
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 23
IP  - 6
DP  - 2008 Nov
TI  - Systemic inflammation in nonischemic dilated cardiomyopathy.
PG  - 445-50
LID - 10.1007/s00380-008-1075-4 [doi]
AB  - We investigated links between inflammatory systemic activation and clinical 
      presentation of nonischemic dilated cardiomyopathy (NIDC). Thirty-one consecutive 
      patients with NIDC (age 57 +/- 10 years, left ventricular ejection fraction 32% 
      +/- 7%) were enrolled in the study: subjects with ischemic heart disease, 
      valvular heart disease, congenital malformations, pulmonary, renal, inflammatory, 
      or metabolic diseases were excluded. All patients underwent physical examination, 
      electrocardiography, chest radiology, echocardiography, and coronary angiography. 
      Plasma levels of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), 
      and fibrinogen were ascertained. New York Heart Association (NYHA) functional 
      class was significantly correlated with concentrations of fibrinogen (r = 0.42, P 
      < 0.05) and CRP (r = 0.52, P < 0.01), and with ESR (r = 0.46, P < 0.05). Left 
      ventricular ejection fraction was inversely related to fibrinogen (r = -0.41, P < 
      0.05) and ln CRP (r = -0.46, P < 0.05). Correlations between NYHA class and 
      markers of inflammation remained significant also after correction for age, sex, 
      and cardiovascular risk factors. Ongoing treatment with statins was associated 
      with reduced CRP levels. Inflammatory markers are increased in patients with NIDC 
      proportionally with severity of symptoms and systolic impairment. Systemic 
      inflammation might be related to deterioration of NYHA class.
FAU - De Gennaro, Luisa
AU  - De Gennaro L
AD  - Cardiology Department, University of Foggia, viale L. Pinto 1, 71100 Foggia, 
      Italy.
FAU - Brunetti, Natale Daniele
AU  - Brunetti ND
FAU - Cuculo, Andrea
AU  - Cuculo A
FAU - Pellegrino, Pier Luigi
AU  - Pellegrino PL
FAU - Di Biase, Matteo
AU  - Di Biase M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20081127
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
RN  - 9001-32-5 (Fibrinogen)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Blood Sedimentation
MH  - C-Reactive Protein/*metabolism
MH  - Cardiomyopathy, Dilated/*blood/diagnosis/physiopathology
MH  - Colorimetry
MH  - Diagnosis, Differential
MH  - Echocardiography
MH  - Electrocardiography
MH  - Female
MH  - Fibrinogen/*metabolism
MH  - Humans
MH  - Inflammation/*blood
MH  - Male
MH  - Middle Aged
MH  - Nephelometry and Turbidimetry
MH  - Prognosis
MH  - Radiography, Thoracic
MH  - Stroke Volume/physiology
EDAT- 2008/11/28 09:00
MHDA- 2009/05/08 09:00
CRDT- 2008/11/28 09:00
PHST- 2008/01/15 00:00 [received]
PHST- 2008/06/01 00:00 [accepted]
PHST- 2008/11/28 09:00 [pubmed]
PHST- 2009/05/08 09:00 [medline]
PHST- 2008/11/28 09:00 [entrez]
AID - 10.1007/s00380-008-1075-4 [doi]
PST - ppublish
SO  - Heart Vessels. 2008 Nov;23(6):445-50. doi: 10.1007/s00380-008-1075-4. Epub 2008 
      Nov 27.