PMID- 19037819
OWN - NLM
STAT- MEDLINE
DCOM- 20090312
LR  - 20181201
IS  - 1502-7708 (Electronic)
IS  - 0036-5521 (Linking)
VI  - 44
IP  - 1
DP  - 2009
TI  - Effect of antrectomy in hypergastrinaemic female Japanese cotton rats.
PG  - 32-9
LID - 10.1080/00365520802308011 [doi]
AB  - OBJECTIVE: Female Japanese cotton rats become hypoacidic and hypergastrinaemic 
      from age 2 months and later develop gastric carcinomas in the oxyntic mucosa. 
      Previous studies have demonstrated that carcinogenesis can be halted by a gastrin 
      receptor antagonist and that carcinomas can be induced by a histamine-2 receptor 
      antagonist or partial corpectomy, both of which induce hypergastrinaemia. The aim 
      of the present study was to examine the effect of antrectomy in female cotton 
      rats. MATERIAL AND METHODS: The animals were either antrectomized (Group 1) or 
      sham-operated (Group 2) 2 months after detection of hypergastrinaemia and 
      terminated 4 months after operation. A third group was antrectomized at age 2 
      months while still normo-acidic (Group 3) and terminated 6 months after 
      operation. RESULTS: Antrectomy after 2 months of hypergastrinaemia prevented the 
      development of carcinoma compared with in sham-operated animals, whereas some of 
      the animals that were antrectomized at 2 months of age also developed carcinomas. 
      In Groups 1 and 2 as well as in animals developing carcinomas in Group 3, there 
      was marked hyperplasia of neuroendocrine cells in the oxyntic mucosa expressing 
      chromogranin A, vesicular monoamine transporter (VMAT)-2, ghrelin and 
      somatostatin. Gastrin-positive cells were found adjacent to neoplastic areas in 
      the oxyntic mucosa. CONCLUSIONS: The removal of antral gastrin by antrectomy 
      halts carcinogenesis in cotton rats, but other mechanisms may also play a role.
FAU - Bakkelund, Karin
AU  - Bakkelund K
AD  - Department of Cancer Research and Molecular Medicine, Faculty of Medicine, NTNU, 
      Trondheim, Norway. karin.bakkelund@ntnu.no
FAU - Fossmark, Reidar
AU  - Fossmark R
FAU - Nordrum, Ivar S
AU  - Nordrum IS
FAU - Waldum, Helge L
AU  - Waldum HL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Scand J Gastroenterol
JT  - Scandinavian journal of gastroenterology
JID - 0060105
RN  - 0 (Gastrins)
RN  - 0 (Hormones)
SB  - IM
MH  - Animals
MH  - Carcinoma/metabolism/pathology/*prevention & control
MH  - Disease Models, Animal
MH  - Female
MH  - *Gastrectomy/methods
MH  - Gastrins/*metabolism
MH  - Hormones/*metabolism
MH  - Pyloric Antrum/metabolism/pathology/*surgery
MH  - Sigmodontinae
MH  - Stomach Neoplasms/metabolism/pathology/*prevention & control
EDAT- 2008/11/28 09:00
MHDA- 2009/03/13 09:00
CRDT- 2008/11/28 09:00
PHST- 2008/11/28 09:00 [pubmed]
PHST- 2009/03/13 09:00 [medline]
PHST- 2008/11/28 09:00 [entrez]
AID - 906044764 [pii]
AID - 10.1080/00365520802308011 [doi]
PST - ppublish
SO  - Scand J Gastroenterol. 2009;44(1):32-9. doi: 10.1080/00365520802308011.