PMID- 19037915
OWN - NLM
STAT- MEDLINE
DCOM- 20090129
LR  - 20211020
IS  - 1365-3164 (Electronic)
IS  - 0959-4493 (Print)
IS  - 0959-4493 (Linking)
VI  - 19
IP  - 6
DP  - 2008 Dec
TI  - The mouse hairy ears mutation exhibits an extended growth (anagen) phase in hair 
      follicles and altered Hoxc gene expression in the ears.
PG  - 358-67
LID - 10.1111/j.1365-3164.2008.00709.x [doi]
AB  - The mouse In(15)2Rl (hairy ears, Eh) mutation is a paracentric inversion of the 
      distal half of chromosome 15 (Chr 15). Heterozygous Eh/+ mice display misshaped 
      and hairy ears that have more and longer hair than the ears of their wild-type 
      littermates. We mapped, cloned and sequenced both inversion breakpoints. No 
      protein-coding transcript was disrupted by either breakpoint. The proximal 
      breakpoint is located between syntrophin basic 1 (Sntb1) and hyaluronan synthase 
      2 (Has2), and the distal breakpoint maps between homeobox C4 (Hoxc4) and 
      single-strand selective monofunctional uracil DNA glycosylase (Smug1), near the 
      middle and the telomere ends of Chr 15, respectively. The inversion spans ~47 
      megabases. Our genetic analysis suggests that the hairy-ear phenotype is caused 
      by the proximal breakpoint of the inversion-bearing Chr 15. Quantitative RNA 
      analysis by real-time polymerase chain reaction for the genes flanking the 
      breakpoint indicated no changes in expression levels except for some homeobox C 
      (Hoxc) genes whose expression was elevated in developing and mature skin of the 
      ears but not of other body regions. The increased hair length on the ears of Eh/+ 
      mice was due to an extension of the anagen stage in the hair cycle, as determined 
      by histological analysis. Our data indicate that the Eh phenotype arises from 
      mis-expression of Hoxc genes.
FAU - Mentzer, Sarah E
AU  - Mentzer SE
AD  - Mammalian Genetics and Genomics Group, Life Sciences Division, Oak Ridge National 
      Laboratory, PO Box 2008, Bethel Valley Road, Oak Ridge, TN 37831-6445, USA.
FAU - Sundberg, John P
AU  - Sundberg JP
FAU - Awgulewitsch, Alexander
AU  - Awgulewitsch A
FAU - Chao, Hanna H J
AU  - Chao HH
FAU - Carpenter, Donald A
AU  - Carpenter DA
FAU - Zhang, Wei-Dong
AU  - Zhang WD
FAU - Rinchik, Eugene M
AU  - Rinchik EM
FAU - You, Yun
AU  - You Y
LA  - eng
GR  - CA34196/CA/NCI NIH HHS/United States
GR  - AR000173/AR/NIAMS NIH HHS/United States
GR  - R01 AR017346/AR/NIAMS NIH HHS/United States
GR  - R01 AR017346-38/AR/NIAMS NIH HHS/United States
GR  - P30 CA034196/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20081114
PL  - England
TA  - Vet Dermatol
JT  - Veterinary dermatology
JID - 9426187
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Hoxc4 protein, mouse)
SB  - IM
MH  - Animals
MH  - Chromosome Inversion/*genetics
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - Ear/*physiology
MH  - Female
MH  - Gene Expression Regulation/*genetics
MH  - Genotype
MH  - Hair/*growth & development/ultrastructure
MH  - Homeodomain Proteins/*genetics/metabolism
MH  - Male
MH  - Mice
MH  - Mutation
PMC - PMC3061202
MID - NIHMS236111
COIS- Conflict of interest - None declared
EDAT- 2008/11/29 09:00
MHDA- 2009/01/30 09:00
PMCR- 2011/03/19
CRDT- 2008/11/29 09:00
PHST- 2008/11/29 09:00 [pubmed]
PHST- 2009/01/30 09:00 [medline]
PHST- 2008/11/29 09:00 [entrez]
PHST- 2011/03/19 00:00 [pmc-release]
AID - VDE709 [pii]
AID - 10.1111/j.1365-3164.2008.00709.x [doi]
PST - ppublish
SO  - Vet Dermatol. 2008 Dec;19(6):358-67. doi: 10.1111/j.1365-3164.2008.00709.x. Epub 
      2008 Nov 14.