PMID- 19039317
OWN - NLM
STAT- MEDLINE
DCOM- 20090414
LR  - 20090126
IS  - 1930-7381 (Print)
IS  - 1930-7381 (Linking)
VI  - 17
IP  - 2
DP  - 2009 Feb
TI  - Interleukin-18 protein level is upregulated in adipose tissue of obese mice.
PG  - 393-5
LID - 10.1038/oby.2008.535 [doi]
AB  - In this study, we investigated the regulation of Interleukin-18 (IL-18) and 
      caspase-1 mRNA and protein levels in adipose and liver tissue of obese (ob/ob) 
      mice compared with ob/+ mice. In ob/ob mice, which have a twofold higher IL-18 
      plasma level as compared with lean mice, IL-18 mRNA expression was significantly 
      reduced by 1.6-fold in adipose tissue, whereas protein level was enhanced 
      fourfold as compared with ob/+ mice. However, caspase-1 mRNA expression and 
      activity were significantly enhanced in adipose tissue of ob/ob mice. Conversely, 
      both IL-18 mRNA and protein levels were slightly enhanced, but caspase-1 activity 
      was reduced in liver of ob/ob mice as compared with lean mice. In conclusion, we 
      show that adipose and hepatic IL-18 protein expressions are increased in obese 
      mice. However, in contrast to liver, the adipose IL-18 protein level appears to 
      be upregulated through a post-transcriptional mechanism probably involving 
      caspase-1.
FAU - Membrez, Mathieu
AU  - Membrez M
AD  - Department of Nutrition and Health, Nestle Research Center, Lausanne, 
      Switzerland.
FAU - Ammon-Zufferey, Corinne
AU  - Ammon-Zufferey C
FAU - Philippe, David
AU  - Philippe D
FAU - Aprikian, Olivier
AU  - Aprikian O
FAU - Monnard, Irina
AU  - Monnard I
FAU - Mace, Katherine
AU  - Mace K
FAU - Darimont, Christian
AU  - Darimont C
LA  - eng
PT  - Journal Article
DEP - 20081127
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
RN  - 0 (Interleukin-18)
RN  - 0 (RNA, Messenger)
RN  - EC 3.4.22.36 (Caspase 1)
SB  - IM
MH  - Adipose Tissue/*metabolism
MH  - Animals
MH  - Caspase 1/genetics/metabolism
MH  - Disease Models, Animal
MH  - Interleukin-18/genetics/*metabolism
MH  - Liver/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Obese
MH  - Obesity/*metabolism
MH  - RNA, Messenger/metabolism
MH  - *Up-Regulation
EDAT- 2008/11/29 09:00
MHDA- 2009/04/15 09:00
CRDT- 2008/11/29 09:00
PHST- 2008/11/29 09:00 [pubmed]
PHST- 2009/04/15 09:00 [medline]
PHST- 2008/11/29 09:00 [entrez]
AID - oby2008535 [pii]
AID - 10.1038/oby.2008.535 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2009 Feb;17(2):393-5. doi: 10.1038/oby.2008.535. Epub 
      2008 Nov 27.